| 吕晓娟,陈书平.新生儿败血症血清高迁移率族蛋白 B1、线粒体偶联因子 -6表达及其与炎症反应及心肌损害的关系[J].安徽医药,2021,25(8):1647-1650. |
| 新生儿败血症血清高迁移率族蛋白 B1、线粒体偶联因子 -6表达及其与炎症反应及心肌损害的关系 |
| Expressions of serum HMGB1 and CF-6 in the newborn with neonatal sepsis and its correla? tion with inflammatory response and myocardial damage |
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| DOI：10.3969/j.issn.1009-6469.2021.08.040 |
| 中文关键词: 脓毒症 新生儿败血症 高迁移率族蛋白 B1 线粒体偶联因子 -6 C反应蛋白 肿瘤坏死因子 -α 心肌肌钙蛋白 I 婴儿，新生 |
| 英文关键词: Sepsis Neonatal sepsis High mobility group protein B1 Mitochondrial coupling factor-6 C-reactive protein Tumor necrosis factor-α Cardiac troponin I Infant, newborn |
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| 中文摘要: |
| 目的探讨新生儿败血症血清高迁移率族蛋白 B1(HMGB1)、线粒体偶联因子 -6(CF-6)表达及其与炎症反应的关系和对心肌损害的预测价值。方法选取 2016年 3月至 2019年 3月洛阳市第一人民医院收治的新生儿败血症病儿 94例，根据新生儿危重症评分结果分非危重组( 39例)、危重组( 26例)、极危重组( 29例)。对比三组血清 HMGB1、CF-6、炎性因子［ C反应蛋白( CRP)、肿瘤坏死因子 -α(TNF-α)］、心肌损害标志物［心肌肌钙蛋白 I(cTnI)、心型脂肪酸结合蛋白( H-FABP)］水平， Pearson相关系数分析血清 HMGB1、CF-6与炎性因子、心肌损害标志物相关性， ROC曲线分析血清 HMGB1、CF-6对心肌损害预测价值。结果随病情加重，血清 HMGB1、CF-6、CRP、TNF-α、cTnI、H-FABP水平呈升高趋势。 Pearson相关系数分析显示，新生儿败血症病儿血清 HMGB1、CF-6表达与 CRP、TNF-α、cTnI、H-FABP呈正相关( P<0.05)。血清 HMGB1、CF-6对心肌损害的预测价值较高，其中 CF-6指标敏感度最高( 0.922)HMGB1的特异度最高( 0.869)。血清 HMGB1、CF-6联合检测对心肌损害的预测价值更高:灵敏度和特异度分别为0.944和0.92，5。结论新生儿败血症病儿存在血清 HMGB1、CF-6表达异常升高情况，且与病儿炎症反应、心肌损害严重程度关系密切，可作为心肌损害的预测因子，对指导临床合理制定治疗方案具有重要意义。 |
| 英文摘要: |
| Objective To measure the expressions of serum high mobility group protein B1 (HMGB1) and mitochondrial coupling factor-6 (CF-6) in neonatal sepsis and to explore its correction with inflammatory reaction and predictive value for myocardial damage. Methods Ninety-four newborn babies with neonatal sepsis hospitalized in The First People's Hospital of Luoyang from March 2016 toMarch 2019 were selected as subjects and assigned into non-critical group (n=39), critical group (n=26), and extremely critical group (n =29) according to neonatal critical illness score. Levels of serum HMGB1, CF-6, inflammatory factors [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α)], myocardial damage markers [cardiac troponin I (cTnI), cardiac fatty acid binding protein (H-FABP)] were compared among three groups. Pearson correlation was adopted to analyze the correlation of serum HMGB1 and CF-6 with inflammatory factors and myocardial damage markers, and ROC curve was used to analyze the value of serum HMGB1 and CF-6 in predicting myocardial damage.Results Levels of serum HMGB1, CF-6, CRP, TNF-α, cTnI and H-FABP increased along with the aggravation of disease. Pearson correlation coefficient analysis showed that the expressions of serum HMGB1 and CF-6 were positively correlated with CRP, TNF-α, cTnI, H-FABP in children with neonatal sepsis (P<0.05). Predictive value of HMGB1 and CF-6 in serum for myocardial damage was high, with the highest sensitivity of CF-6 (0.922), and the highest specificity of HMGB1 (0.869). A combined application of serum HMGB1 and CF-6 had higher predictive value: sensitivity and specificity were 0.944 and 0.925, respectively.Conclusions Expressions of serum HMGB1 and CF-6 are abnormally elevated in children with neonatal sepsis, and they are closely related to inflammatory reaction and severity of myocardial damage in children with neonatal sepsis. Therefore, they can be used as predictors for myocardial damage, which has great significance in making rational treatment protocols. |
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