| 李昂庆,徐阿曼.术前血小板与淋巴细胞比值、淋巴细胞与单核细胞比值与胃癌病人预后的关系[J].安徽医药,2021,25(8):1651-1655. |
| 术前血小板与淋巴细胞比值、淋巴细胞与单核细胞比值与胃癌病人预后的关系 |
| Association between PLR,LMR and prognosis of patients with gastric cancer |
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| DOI：10.3969/j.issn.1009-6469.2021.08.041 |
| 中文关键词: 胃肿瘤 血小板与淋巴细胞比值 淋巴细胞与单核细胞比值 联合 预后 |
| 英文关键词: Stomach neoplasms Platelet to lymphocyte ratio Lymphocyte to monocyte ratio Combined Prognosis |
| 基金项目: |
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| 中文摘要: |
| 目的探讨术前血小板与淋巴细胞比值(PLR)、淋巴细胞与单核细胞比值( LMR)与胃癌病人预后的关系。方法收集安徽医科大学第一附属医院 2015年 10月至 2017年 4月收住的胃癌病人 900例，根据 3年生存率绘制的受试者工作特征(ROC)曲线确定 PLR及 LMR值的截点，分为低 PLR组( PLR<140.35)、高 PLR组( PLR≥140.35)和低 LMR组( LMR<4.88)、高 LMR组( LMR≥4.88)四组，比较四组临床病理资料，采用单因素及多因素分析影响胃癌病人预后的因素，比较各组生存期和生存率，绘制相应生存曲线。结果低 PLR组与高 PLR组癌胚抗原( CEA)CA19-9、T分期、 N分期、病理学 TNM分期、鲍曼分型、分化程度、肿瘤直径及 3年生存状态比较，均差异有统计学意义(P<0.05)、低 LMR组和高 LMR组性别、年龄、 CEA、CA19-9、T分期、 N分期、病理学 TNM分期、鲍曼分型、肿瘤直径及 3年生存状态比较，，均差异有统计学意义( P<0.05)COX回归分析显示， CEA、CA19-9、TNM分期、肿瘤直径及 LMR是胃癌病人预后的独立影响因素。 3年总生存率比较，低 PLR组，和高 PLR(88.0%比 46.7%)低 LMR组和高 LMR组(56.9%比 89.9%)，均差异有统计学意义( P<0.05)。低 PLR高 LMR组、高 PLR高 LMR组、低 PLR及高 PLR低 LMR组生存期分别为( 55.801±0.509)月，( 49.306±1.461)月，( 49.634±1.017)月，( 27.884±1.242)月， 3年生存率分别为 94.4%、76.4%、79.5%、30.0%，四组生存率比较，差异有统计学意义( P<0.008)。结论术前高 PLR及低 LMR是低LMR组，影响胃癌病人预后的独立危险因素。高 PLR低 LMR的胃癌病人预后更差。 |
| 英文摘要: |
| Objective To explore the correlation between preoperative platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio(LMR) and prognosis of patients with gastric cancer.Methods A total of 900 patients with gastric cancer admitted to The First Affiliated Hospital of Anhui Medical University from October 2015 to April 2017 were enrolled in the study. According to the 3-year survival rate of these patients, the receiver operating characteristic (ROC) curve was drawn to determine the cut-off points of PLR and LMR values to further assign these patients into four groups: low PLR group (PLR<140.35), high PLR group (PLR≥140.35), low LMR group(LMR<4.88) and high LMR group (LMR≥4.88). The clinicopathological data of the four groups were compared, and univariate and multivariate analysis were used to find out the factors affecting the prognosis of patients with gastric cancer. The survival time and survivalrates of the groups were compared, and the corresponding survival curves were drawn.Results There were significant differences in carcinoembryonic antigen (CEA), CA19-9, T staging, N staging, pathological TNM staging, Borrmann classification, degree of differentiation, tumor size and 3-year survival status between low PLR group and high PLR group (P<0.05), and there were significant differences in gender, age, CEA, CA19-9, T staging, N staging, pathological TNM staging, Borrmann classification, tumor size and 3-year survival status between low LMR group and high LMR group (P<0.05). COX regression analysis results showed that CEA, CA19-9, TNM staging, tumor size and LMR were independent prognostic factors of patients with gastric cancer. Survival analysis showed that there werestatistical differences in the overall 3-year survival rates between low PLR group and high PLR group (88.0% vs. 46.7%), and between low LMR group and high LMR group (56.9% vs. 89.9%)(P<0.05). The patients were further assigned into four groups: low PLR and highLMR group, high PLR and high LMR group, low PLR and low LMR group, high PLR and low LMR group. The average survival timewas (55.801±0.509) months, (49.306±1.461) months, (49.634±1.017) months and (27.884±1.242) months, respectively.The 3-year survival rates were 94.4%, 76.4%, 79.5% and 30.0%. There was significant difference in the overall survival rate among the four groups (P <0.008).Conclusion Preoperative high PLR and low LMR are independent risk factors affecting the prognosis of patients with gastriccancer. And the prognosis of those with high PLR and low LMR is worse than other patients. |
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