| 李丽,吴志鸿.Toll样受体 4与原发性开角型青光眼关系的研究进展[J].安徽医药,2021,25(10):1916-1920. |
| Toll样受体 4与原发性开角型青光眼关系的研究进展 |
| Research progress on the relationship between toll-like receptor 4 and primary open-angle glaucoma |
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| DOI：10.3969/j.issn.1009-6469.2021.10.002 |
| 中文关键词: Toll样受体 4 青光眼，开角型 转化生长因子 -β 小梁网 基因多态性 视网膜神经节细胞 综述 |
| 英文关键词: Toll-like receptor 4 Glaucoma,open-angle Transforming growth factor-β Trabecular meshwork Gene polymorphism Retinal ganglion cells Review |
| 基金项目:北航 -首医大数据精准医疗高精尖创新中心同仁分中心开放基金项目( BHTR-KFJJ-202017) |
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| 中文摘要: |
| Toll样受体 4(Toll-like recepters，TLR4)是目前 TLR家族中发现最早且研究最为深入的一个重要分子，它是脂多糖( lipopolysaccharide，LPS)的主要受体， TLR4的激活能刺激机体释放多种炎性因子，使机体产生天然免疫反应。原发性开角型青光眼( primary open angle glaucoma，POAG)是一种慢性、进行性的视神经退行性疾病，世界卫生组织将其列为世界第二大致盲眼病。一些研究表明， POAG与免疫反应密切相关，是一种自身免疫疾病。 TLR4出现在 POAG的小梁网( trabecular meshwork， TM)和视网膜神经节细胞( retinal ganglion cell，RGC)中，与青光眼的发生密切相关。近几年来大家对 TLR4的结构、信号通路及其在 POAG发病机制和治疗中的作用有了初步的了解，本研究就 TLR4与 POAG关系的研究进展结果做一总结。 |
| 英文摘要: |
| Toll-like receptor 4 (TLR4) is the earliest and most deeply studied important molecule in the TLR family, which is themain receptor of lipopolysaccharides (LPS). TLR4 can stimulate the body to release a variety of inflammatory factors, causing the bodyto produce a natural immune response. Primary open-angle glaucoma (POAG) is a chronic and progressive optic nerve degenerative disease, which is ranked as the world's second blinding eye disease by the World Health Organization. Some studies have shown that POAG is closely related to immunity and is an autoimmune disease. TLR4 appears in the trabecular meshwork (TM) and retinal ganglioncells (RGC) of POAG and is closely related to glaucoma. In recent years, researchers have a preliminary understanding of the structureand signal pathway of TLR4, as well as its pathogenesis and therapeutic effect in POAG. This study summarizes the research resultsand progresses on the relationship between TLR4 and POAG. |
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