| Objective To explore the correlation between alopecia areata and thyroid diseases and related indicators.Methods Literature published from April 1989 to April 2019 was retrieved via a literature search of Wanfang Database, CNKI, CBM, VIP, SCIEand PubMed . The relevant literatures, which met the inclusion and exclusion criteria, were selected. After quality evaluation, R software was used to analyze the correlation between alopecia areata and thyroid disease, thyroid autoantibodies, and thyroid function.Re? sults A total of 18 papers were included, involving 268 713 patients with alopecia areata and 1 345 687 people without alopecia areata. Meta-analysis results showed that alopecia areata was correlated with the following diseases and indicators: Hashimoto's thyroiditis1.21 (1.13,1.29), Graves' disease 1.53 (1.43,1.63), thyroid peroxidase antibody (TPOAb) 4.39 (2.75,7.01), thyroglobulin antibody(TGAb) 2.82 (1.45,5.47), increased thyroxine (T4) 2.92 (1.15, 7.43); alopecia areata was uncorrelated with the following diseases and indicators: hyperthyroidism 0.47 (0.16,1.41), hypothyroidism 1.86 (0.63,5.51), increased triiodothyronine (T3) 2.00 (0.64,6.27), increasedthyroid stimulating hormone (TSH) 1.07 (0.56,2.04). There was only one included case with declined T4, T3 and TSH, thus no metaanalysis was conducted.Conclusion Alopecia areata was associated with Hashimoto's thyroiditis, Graves' disease, TPOAb,TGAb,and increased T4. It was not related to hyperthyroidism, hypothyroidism, increased T3 and increased TSH. |
