| 姚若愚,展浩,鲍强,等.纤维蛋白原与淋巴细胞比值在评估老年食管鳞癌放疗预后中的价值[J].安徽医药,2021,25(10):1972-1976. |
| 纤维蛋白原与淋巴细胞比值在评估老年食管鳞癌放疗预后中的价值 |
| The value of fibrinogen to lymphocyte ratio in evaluating the prognosis of elderly patients with esophageal squamous cell carcinoma |
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| DOI：10.3969/j.issn.1009-6469.2021.10.015 |
| 中文关键词: 食管肿瘤 纤维蛋白原 淋巴细胞计数 纤维蛋白原与淋巴细胞比值 预后 老年人 |
| 英文关键词: Esophageal neoplasms Fibrinogen Lymphocyte count Fibrinogen to lymphocyte ratio Prognosis Aged |
| 基金项目:江苏省自然科学基金项目( BK20151156) |
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| 中文摘要: |
| 目的探讨纤维蛋白原与淋巴细胞比值( FLR)所建立的新型预测模型在评价老年食鳞癌病人放疗近期疗效和预后的价值。方法收集 2014年 1月至 2018年 1月徐州医科大学附属医院放射治疗科接受放射治疗并符合入组条件的老年食管癌 127例资料。根据受试者 ROC曲线求得纤维蛋白原与淋巴细胞比值对的最佳截断值，并以此计算 FLR水平与食管鳞癌临床病理特征和预后的关系。结果受试者工作特征曲线( ROC)显示，放疗前 FLR的最佳截断值为 2.05。根据 2.05将 127例病人分为低 FLR(n=56例)和高 FLR(n=71例)。不同 FLR水平病人累积生存率经 log-rank检验结果显示， FLR高水平病人共 56例，生存时间为( 23.87±4.05)月， FLR低水平组共 71例，生存时间为( 55.21±3.99)月， FLR高水平者明显低于 FLR低水平者，差异有统计学意义( P<0.05)。低 FLR组放疗有效率为 91.0%，高 FLR组有效率为 71.8%，差异有统计学意义( P<0.05)。单因素分析显示， FLR、N分期、 T分期、 TNM分期是影响老年食管鳞癌病人总生存( Overall survival，OS)的因素，多因素分析显示， FLR、N分期是影响老年食管鳞癌病人 OS的因素。结论高水平的 FLR提示老年食管鳞癌病人放疗近期疗效、预后均较差。 |
| 英文摘要: |
| Objective To explore the value of a new prediction model based on the ratio of fibrinogen to lymphocyte (FLR) in evaluating the short-term efficacy and prognosis of radiotherapy in elderly patients with esophagal squamous cell carcinoma.Methods From January 2014 to January 2018,127 elderly patients withesophageal cancer whoreceived radiotherapy in the Radiotherapy Department of Affiliated Hospital of Xuzhou Medical University were collected. According to the operating characteristic curve (ROC) of the subjucts, the bestcutoff value ofthe fibrinogen to lymphocyte ratio was obtained,and the relationship between FLR level and clinicopathological characteristics and prognosis of ESCC was calculated.Results ROC showed that the best cutoff value of FLR before radiotherapy was 2.05. According to 2.05, 127 patients were divided into low FLR (n=56) and high FLR (n=71). The cumulative survival rate of patients with different FLR levels by log-rank test showed that 56 patients with high FLR had a survival time of (23.87 ± 4.05) months, and 71 patients with lowFLR had a survival time of (55.21 ± 3.99) months. The survival time in patients with high FLR level was significantly lower than that of thelow FLR level, and the difference was statistically significant (P <0.05), and the effective rate in the high FLR group was 71.8%. The difference was statistically significant (P<0.05). Single factor analysis showed that FLR, N stage, T stage and TNM stage were the factors influencing the overall survival (OS) of elderly patients with esophageal squamous cell carcinoma. Multi-factor analysis showed that FLR and N stage were the factors influencing OS in elderly patients with esophageal squamous cell carcinoma.Conclusion High level of FLR is indicativeofpoorshort-term efficacyand prognosisofradiotherapyin the elderlypatientswithesophageals |
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