文章摘要
吕奇,张莉莉,冯婷.皮肤性病 60例的人乳头瘤病毒感染型别分析[J].安徽医药,2021,25(10):2064-2066.
皮肤性病 60例的人乳头瘤病毒感染型别分析
Analysis of human papillomavirus infection types in 60 cases of skin venereal diseases
  
DOI:10.3969/j.issn.1009-6469.2021.10.036
中文关键词: 乳头状瘤病毒感染  性传播疾病  皮肤性病  人乳头瘤病毒  感染型别  临床检测
英文关键词: Papillomavirus infections  Sexually transmitted diseases  Dermatosexually transmitted diseases  Human papilloma virus  Infection types  Clinical detection
基金项目:
作者单位
吕奇 淮南市第一人民医院皮肤性病科安徽淮南 232007 
张莉莉 淮南市第一人民医院皮肤性病科安徽淮南 232007 
冯婷 淮南市第一人民医院皮肤性病科安徽淮南 232007 
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中文摘要:
      目的探讨皮肤性病病人不同病变类型中的人乳头瘤病毒( HPV)感染型别的检测和分析结果。方法选取淮南市第一人民医院 2018年 2月至 2019年 2月收治的 60例皮肤性病病人作为研究对象,对所有病人均利用 PCR-反向斑点杂交法进行 HPV-DNA分型的检测,并对皮肤性病病人不同病变类型中 HPV感染的型别进行统计和比较。结果本研究 60例标本中 HPV-DNA检测阳性例数为 71.67%(43/60);其中 HPV单一型的 31例,占比 72.09%(31/43); HPV2种或以上者共 12例,占比 27.91%(12/43)。 43例 HPV检测阳性标本中高危型检出例数最高,为 24例,占比 55.81%;低危型 13例,占比 30.23%;混合型 6例,占比 13.95%。本研究不同病变类型皮肤性病中,以尖锐湿疣的 HPV感染阳性率最高,为 76.47%(26/30);鲍温样丘疹病次之阳性率为 66.67%(10/15);其次为冠状沟珍珠疹和假性湿疣,阳性率分别为 50%(4/8)和 42.86%(3/7)。在 HPV感染型别上,以尖锐湿疣类别最多,包括了 6、11、16、18、31、33、35、43和 66,而鲍温样丘疹病主要为 16,男性冠状沟珍珠疹主要为低危型的 6、42、43和 81,女性假性湿疣也为低危型的 6、42、83。结论皮肤性病病人 HPV感染存在不同的类别,因此临床上在诊断时需要积极开展相应的检测工作,从而为临床治疗方案的设定和预后结果的判断提供参考依据。
英文摘要:
      Objective To investigate the detection and analysis of human papillomavirus (HPV) infection types in patients with dermatovenereal diseases.Methods Sixty patients with dermatosexually transmitted diseases (STDs) admitted to Huainan First People'shospital from February 2018 to February 2019 were selected as the research objects, all patients were detected for HPV-DNA typing by PCR-reverse dot hybridization, the types of HPV infection in different pathological types of skin venereal diseases were analyzed andcompared.Results The positive rate of HPV-DNA was 71.67% (43/60) in 60 samples, among them, 31 cases were single HPV, accounting for 72.09% (31/43); 12 cases were HPV or more, accounting for 27.91% (12/43). Among 43 HPV positive specimens, the number of high-risk types was the highest, 24 cases, accounting for 55.81%; 13 cases of low-risk types, accounting for 30.23%; 6 cases ofmixed type, accounting for 13.95%. Among the skin and venereal diseases of different pathological types, condyloma acuminatum hadthe highest positive rate of HPV infection, 76.47% (26/30); bowen-like papulosis followed by a positive rate of 66.67% (10/15); followed by coronary pearl rash and pseudocondyloma, with a positive rate were 50% (4/8) and 42.86% (3/7) respectively. Among HPV infectiontypes, condyloma acuminatum was the most types, including 6, 11, 16, 18, 31, 33, 35, 43 and 66, while bowen-like papulosis was 16, pearl eruption in male coronary sulcus was 6, 42, 43 and 81, and pseudocondyloma in female was 6, 42 and 83.Conclusion There are different types of HPV infection in patients with dermatosexually transmitted diseases, so it is necessary to actively carry out the corre sponding detection work in clinical diagnosis, so as to provide reference for the setting of clinical treatment programs and the judgment
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