| 苑彩云,苏峰,刘加宁,等.枳术颗粒联合叶酸治疗幽门螺旋杆菌阳性慢性萎缩性胃炎 46例[J].安徽医药,2021,25(10):2105-2109. |
| 枳术颗粒联合叶酸治疗幽门螺旋杆菌阳性慢性萎缩性胃炎 46例 |
| Curative effect of Zhizhu granule combined with folic acid on helicobacter pylori-positive chronic atrophic gastritis:an analysis of 46 cases |
| |
| DOI：10.3969/j.issn.1009-6469.2021.10.046 |
| 中文关键词: 胃炎，萎缩性 枳术颗粒 叶酸 四联疗法 胃泌素类 幽门螺旋杆菌(Hp) |
| 英文关键词: Gastritis,atrophic Zhizhu granule Folic acid Quadruple therapy Gastrins Helicobacter pylori (Hp) |
| 基金项目: |
|
| 摘要点击次数: 1402 |
| 全文下载次数: 414 |
| 中文摘要: |
| 目的探讨枳术颗粒联合叶酸对幽门螺旋杆菌( Hp)阳性慢性萎缩性胃炎病人的治疗作用。方法选取 2016年 1月至 2018年 12月宿迁市人民医院收治的 92例 Hp阳性慢性萎缩性胃炎病人，采用随机数字表法分为对照组与观察组，每组 46例。对照组在四联疗法的基础上给予叶酸治疗， 10毫克 /次， 3次/天，治疗 2周；观察组在对照组的基础上给予枳术颗粒治疗， 6克/次， 3次/天，治疗 2周。比较两组病人的临床疗效、临床症状积分、胃黏膜病理积分、血清中炎性因子含量、胃泌素与胃蛋白酶原( PG)含量、 Hp清除率、不良反应。结果观察组的总有效率( 86.96%)高于对照组( 67.39%)(P<0.05)。治疗后，与对照组相比，观察组的临床症状(胃痛、胃中嘈杂、胃脘胀满、嗳气反酸、乏力)积分、胃黏膜病理积分(炎症、病变活动度、腺体萎缩、肠上皮化生)、血清炎性因子［白细胞介素 -1β(IL-1β)、白细胞介素 -8(IL-8)、肿瘤坏死因子 -α(TNF-α)］含量、血清胃蛋白酶原 Ⅱ(PGⅡ)含量均降低( P<0.05)血清胃泌素、胃蛋白酶原 Ⅰ(PGⅠ)含量均升高( P<0.05)。观察组的 Hp清除率( 95.65%)高于对照组( 78.26%)(P<0.05)。两组不，良反应发生率比较差异无统计学意义( P>0.05)。结论在四联疗法的基础上给予枳术颗粒和叶酸联合治疗，可以增强 Hp阳性慢性萎缩性胃炎病人的治疗效果，改善临床症状和胃黏膜病变程度，降低炎症水平，调节胃泌素和胃蛋白酶原表达，提高 Hp清除率，具有较好的药物安全性。 |
| 英文摘要: |
| Objective To explore the therapeutic effect of Zhizhu granule combined with folic acid on patients with Helicobacter pylori (Hp)-positive chronic atrophic gastritis.Methods A total of 92 patients with Hp-positive chronic atrophic gastritis admitted to Suqian People's Hospital from January 2016 to December 2018 were randomly assigned into control group and observation group using adigital random number table, with 46 cases in each group. The control group was treated with folic acid (10 mg t.i.d. for 2 weeks) on thebasis of quadruple therapy, and the observation group was given additional Zhizhu granule (6 g t.i.d. for 2 weeks). The clinical efficacy,clinical symptom scores, gastric mucosal pathological scores, serum inflammatory factor levels, gastrin and pepsinogen (PG) levels, Hpclearance rate, and adverse reaction were compared between the two groups.Results The total effective rate of the observation group (86.96%) was higher than that of the control group (67.39%) (P<0.05). After treatment, compared with the control group, clinical symptom scores (stomachache, gastric discomfort, gastric distention, ructus and acid reflux, fatigue), gastric mucosal pathological scores (inflammation, disease activity, gland atrophy, intestinal metaplasia), the levels of serum inflammatory factors [interleukin-1β (IL-1β), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α)] and pepsinogen Ⅱ (PGⅡ) in the observation group were decreased (P<0.05), and the levels of gastrin and pepsinogenⅠ (PGⅠ) in serum were increased (P<0.05). The Hp clearance rate of the observation group (95.65%) was higher than that of the control group (78.26%) (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion On the basis of quadruple therapy, a combination treatment of Zhizhu granule and folic acid can enhance the therapeutic effect of patients with Hp-positive chronic atrophic gastritis, improve clinical symptoms andgastric mucosal pathological lesions, reduce inflammation levels, regulate the expression of gastrin and pepsinogen, improve Hp clearance rate and achieve a good drug safety. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
