| 李汉颖,李汉宇,李增祥.血清微小 RNA-181c、微小 RNA-146a对急性脑梗死病人神经功能缺损及预后的影响[J].安徽医药,2021,25(12):2382-2386. |
| 血清微小 RNA-181c、微小 RNA-146a对急性脑梗死病人神经功能缺损及预后的影响 |
| The influence of serum microRNA-181c and microRNA-146a on neurological deficit and prognosis in patients with acute cerebral infarction |
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| DOI：10.3969/j.issn.1009-6469.2021.12.012 |
| 中文关键词: 脑梗死 神经功能缺损 微小 RNA-181c 微小 RNA-146a 受试者工作特征曲线 显著， |
| 英文关键词: Brain infarction Neurological deficit MicroRNA-181c MicroRNA-146a Receiver operating characteristic curve |
| 基金项目:河南省医学科技攻关计划项目( 201806126) |
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| 中文摘要: |
| 目的探究血清微小 RNA(miR)-181c、miR-146a对急性脑梗死( ACI)病人神经功能缺损及预后的影响。方法选取南阳市中医院 2018年 1月至 2019年 7月 ACI病人 135例作为研究对象，比较不同美国国立卫生院神经功能缺损评分( NIHSS)、不同预后病人血清 miR-181c、miR-146a水平，采用 Pearson相关性分析血清 miR-181c、miR-146a与 NIHSS评分相关性， logistic回归分析血清 miR-181c、miR-146a与预后的关系，受试者工作特征( ROC)曲线分析血清 miR-181c、miR-146a对预后的预测价值，并采用 Kaplan-Meier曲线进行生存分析。结果 NIHSS评分 ≥16分病人血清 miR-181c水平( 1.63±0.14)高于 5~15分( 1.52±0.12)、 <5分( 1.38±0.09)病人， NIHSS评分 ≥16分病人 miR-146a水平( 0.54±0.08)低于 5~15分( 0.67±0.10)、<5分( 0.86±0.13)病人(P<0.05)；血清 miR-181c与 NIHSS评分呈正相关， miR-146a与 NIHSS评分呈负相关( P<0.05)；生存者入院时、入院第 3天血清 miR-181c水平［(1.45±0.20)、(1.20±0.19)］低于死亡者［(1.68±0.25)、(1.53±0.35)］miR-146a水平［(0.74±0.16)、(0.97±0.23)］高于死亡者［( 0.60±0.13)、(0.76±0.15)］(P<0.05)；血清 miR-181c、miR-146a与预后相关( P<0.05)；预测预后的 AUC:入院时第 3天 miR-146a>入院时第 3天 miR-181c>入院时 miR-146a>入院时 miR-181c(P<0.05)； miR-181c高危与低危、 miR-146a高危与低危者生存曲线比较，差异有统计学意义( P<0.05)。结论 ACI病人神经功能缺损与血清 miR-181c呈正相关，与血清 miR-146a呈负相关，并是预后相关影响因素，均具有较高的预后预测价值。 |
| 英文摘要: |
| Objective To explore the effects of serum microRNA-181c and microRNA-146a on neurological deficits and prognosis of patients with acute cerebral infarction (ACI).Methods A total of 135 patients with ACI in Nanyang Hospital of Traditional ChineseMedicine from January 2018 to July 2019 were selected as the research objects, and the levels of serum microRNA-181c and microR. NA-146a in patients with different National Institutes of Health Neurological Impairment Score (NIHSS) and different prognosis werecompared. Pearson analysis was made of the correlation between the levels of serum microRNA-181c, microRNA-146a and NIHSS score . Logistic regression analysis was made of the association between serum microRNA-181c, microRNA-146a and prognosis, receiv.er operating characteristics (ROC) curve analysis was made for determining he predictive value of microRNA-181c and microRNA-146a on the prognosis, and the Kaplan-Meier curve was used for survival analysis.Results The serum microRNA-181c level of pa. tients with NIHSS score ≥16 points was higher than that of 5-15 points and that less than 5 points [ (1.63±0.14) vs. (1.52±0.12) vs. (1.38±0.09)]. The serum microRNA-146a level of patients with NIHSS score ≥16 points was lower than that of 5-15 points and that less than 5 points [(0.54±0.08) vs. (0.67±0.10) vs. (0.86±0.13); P<0.05]. Serum microRNA-181c was positively correlated with NIHSS score, while microRNA-146a was negatively correlated with NIHSS score (P<0.05). The serum microRNA-181c levels [(1.45±0.20), (1.20±0.19)] of the survivors were lower than those of the dead [(1.68±0.25), ( 1.53±0.35)], the levels of microRNA-146a [(0.74±0.16), (0.97± 0.23)] were higher than those of the dead [(0.60±0.13), (0.76±0.15)] (P<0.05) at admission and 3 d after admission. Serum microRNA -181c and microRNA-146a levels were significantly correlated with prognosis (P<0.05). Prediction of AUC for prognosis showed that mi. croRNA-146a 3 d after admission> microRNA-181c 3 d after admission>microRNA-146a at admission> microRNA-181c at admission (P<0.05). Differences were statistically significant between microRNA-181c high-risk and low-risk, microRNA-146a high-risk and low-risk survival curves (P<0.05).Conclusions Neurological deficits in patients with ACI are positively correlated with serum microRNA-181c and negatively correlated with serum microRNA-146a. They are both factors related to prognosis, and both have high prognostic value. |
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