| 董中茂,孙蓓蓓,王晗晶,等.微生态疗法对轮状病毒腹泻病儿内皮糖萼及炎症反应的影响:一项随机、对照、开放研究[J].安徽医药,2021,25(12):2523-2526. |
| 微生态疗法对轮状病毒腹泻病儿内皮糖萼及炎症反应的影响:一项随机、对照、开放研究 |
| Effect of microecological therapy on endothelial glycocalyx and inflammatory response in children with rotavirus diarrhea: a randomized, controlled, open-label study |
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| DOI：10.3969/j.issn.1009-6469.2021.12.044 |
| 中文关键词: 轮状病毒感染 腹泻 微生态疗法 糖萼 炎症 儿童，学龄前 |
| 英文关键词: Rotavirus infections Diarrhea Microecological therapy Glycocalyx Inflammation Child, preschool |
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| 中文摘要: |
| 目的探讨微生态疗法对轮状病毒腹泻病儿内皮糖萼和炎症反应的影响。方法选取 2016年 6月至 2018年 6月在徐州市儿童医院接受治疗的轮状病毒感染确诊病儿 180例，采用随机数字表法分为对照组和观察组，每组各 90例。对照组采用蒙脱石散治疗，观察组在对照组的基础上联合金双歧(双歧杆菌乳杆菌三联活菌片)治疗，治疗时间均为 7d。观察治疗前和治疗后 1d、3d、5d、7d时糖萼损伤标志物［多配体蛋白聚糖 -1(syndecan-1)、硫酸乙酰肝素、透明质酸］水平，利用侧流暗场成像技术测定舌下微循环血管内皮糖萼厚度；观察治疗前后肠黏膜屏障功能指标( D-乳酸、内毒素、降钙素原)水平；观察治疗前后炎性因子(肿瘤坏死因子 -α、白细胞介素 -6、白细胞介素 -17)水平；比较两组病人治疗效果。结果观察组治疗 3d、5d、7d时 syndecan-1、硫酸乙酰肝素、透明质酸水平降低( P<0.05)，舌下微循环血管内皮糖萼厚度治疗后为( 253.32±12.57)mm高于治疗前的(169.29±9.37)mm(P<0.05)；治疗前 D-乳酸、内毒素、降钙素原及炎性因子水平分别为( 5.49±0.99)mg/L、(0.20±0.04)EU/mL和( 0.84±0.18)mg/L，治疗后为( 3.81±0.79)mg/L、(0.11±0.02)EU/mL和( 0.42±0.08)mg/L，与治疗前比较均降低( P<0.05)，且治疗后观察组低于对照组( P<0.05)；观察组治疗总有效率为 90.0%高于对照组 66.67%(P<0.05)。结论微生态疗法可有效修复轮状病毒腹泻病儿肠道内皮糖萼，提高肠黏膜屏障功能，缓解炎症反应。 |
| 英文摘要: |
| Objective To investigate the effect of microecological therapy on endothelial glycocalyx and inflammatory response inchildren with rotavirus diarrhea.Methods One hundred and eighty rotavirus infected children who were treated in Xuzhou Children′sHospital from June 2016 to June 2018 were randomly assigned into control group and observation group by random number table, with90 cases in each group. The control group was treated with montmorillonite powder while the observation group was treated with gold bi.fidobacteria (bifidobacterium bifidum triple live bacteria tablets) on the basis of the control group. The treatment time was 7 days. Thelevels of glycocalyx injury markers (syndecan-1, heparan sulfate, hyaluronic acid levels) before treatment and at 1 day, 3 days, 5 days,and 7 days after treatment were observed. The sublingual microcirculation vascular endothelial glycocalyx thickness were measured bylateral flow dark field imaging. The level of intestinal mucosal barrier function (D-lactic acid, endotoxin, procalcitonin) before and aftertreatment was observed. The levels of inflammatory factors (tumor necrosis factor-α, Interleukin-6, Interleukin-17) before and after treatment were observed. The therapeutic effects of the two groups were compared.Results The levels of syndecan-1, heparan sulfate, and hyaluronic acid decreased in the observation group on the 3rd, 5th, and 7th day of treatment were decreased (P<0.05). The thick.ness of glycocalyx in the sublingual microcirculation vascular endothelium after treatment (253.32±12.57) mm was higher than beforetreatment [(169.29±9.37) mm] (P<0.05). The levels of D-lactic acid, endotoxin, procalcitonin, and inflammatory factors before treatmentwere (5.49±0.99) mg/L, (0.20±0.04) EU/mL and (0.84±0.18) mg/L, respectively. After treatment, they were (3.81±0.79) mg/L, (0.11±0.02) EU/mL and (0.42±0.08) mg/L, which were decreased than before treatment, and those in the observation group were lower thanthose in the control group after treatment (P<0.05). The total effective rate of treatment in the observation group (90.0%) was higher than that in the control group (66.67%) (P<0.05).Conclusion Microecological therapy can effectively repair the intestinal endothelialglycocalyx, improve the intestinal mucosal barrier function, and relieve inflammation in children with rotavirus diarrhea. |
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