| 姚远,万超,刘彩霞,等.穴位注射单唾液酸四己糖神经节苷脂钠治疗小儿脑性瘫痪的临床观察[J].安徽医药,2022,26(5):1039-1043. |
| 穴位注射单唾液酸四己糖神经节苷脂钠治疗小儿脑性瘫痪的临床观察 |
| Clinical observation of acupoint injection of monosialotetrahexosylganglioside sodium in the treatment of children with cerebral palsy |
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| DOI：10.3969/j.issn.1009-6469.2022.05.045 |
| 中文关键词: 脑性瘫痪 儿童 Bobath爬行训练 单唾液酸四己糖神经节苷脂钠 穴位注射 |
| 英文关键词: Cerebral palsy Child Bobath crawling training Monosialotetrahexosylganglioside sodium Acupoint injection |
| 基金项目:湖北省卫健委中医药科研面上项目(2Y2019M047) |
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| 中文摘要: |
| 目的观察穴位注射单唾液酸四己糖神经节苷脂钠(GM1)治疗小儿脑性瘫痪的临床疗效。方法选取2018年7月至2019年9月十堰市太和医院收治的小儿脑性瘫痪病儿35例设为观察组，并选取2017年7月以前收治的35例设为对照组。对照组依据Alberta婴儿运动量表(AIMS)评估结果设定动作并制订康复计划进行Bobath爬行训练治疗6个月，观察组在此治疗基础上于“足三里、曲池和百会”穴位注射GM1 治疗4 个疗程。比较两组治疗前后静脉血乙酰胆碱(Ach)、乙酰胆碱脂酶(AChE)、脑源性神经生长因子(BDNF)含量及脑干听觉诱发电位(BAEP)Ⅰ、Ⅲ和Ⅴ波潜伏期和波幅、Ⅰ～Ⅲ、Ⅲ～Ⅴ、Ⅰ～Ⅴ峰间期。采用粗大运动功能测试量表(GMFM)及精细动作发育商(DQ)比较两组临床疗效。结果观察组治疗后BDNF和Ach含量增加、GMFM及DQ评分较治疗前和对照组明显提高，AChE活性及Ⅴ波阈值和Ⅰ、Ⅲ、Ⅴ波波幅均明显降低，Ⅰ、Ⅲ和Ⅴ波潜伏期及Ⅰ～Ⅲ、Ⅲ～Ⅴ、Ⅰ～Ⅴ峰间期明显延长，临床总有效率达88.57%，与同组治疗前和对照组治疗后比较差异有统计学意义(P<0.05)。结论穴位注射GM1治疗小儿脑性瘫痪安全易行，有利于提高临床疗效，值得推广。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of acupoint injection of monosialotetrahexosylganglioside sodium (GM1) in the treatment of children with cerebral palsy.Methods A total of 35 children with cerebral palsy who were admitted to Taihe Hospital from July 2018 to September 2019 were selected as the observation group, and 35 patients who were admitted before July 2017 were se?lected as the control group. The control group set the movements according to the results of the Alberta Infant Exercise Scale (AIMS)and developed a rehabilitation plan for Bobath crawling training for 6 months. On the basis of this treatment, the observation group re?ceived 4 courses of GM1 injection at "Zusanli, Quchi and Baihui" acupoints. The venous blood acetylcholine (Ach), acetylcholinester?ase (AChE), brain-derived nerve growth factor (BDNF) contents and brainstem auditory evoked potential (BAEP) Ⅰ, Ⅲ and Ⅴ wave la?tencies and amplitudes Ⅰ-Ⅲ, Ⅲ-Ⅴ and Ⅰ-Ⅴ peak intervals were compared between the two groups before and after treatment. The gross motor function test scale (GMFM) and fine motor development quotient (DQ) were used to compare the clinical efficacy of the two groups.Results After treatment, the content of BDNF and Ach in the observation group increased and the GMFM and DQ scores were significantly improved compared with those before treatment and the control group. The AChE activity and V wave threshold and Ⅰ,Ⅲ and Ⅴ wave amplitudes were significantly reduced,Ⅰ,Ⅲ and Ⅴ wave latencies and Ⅰ-Ⅲ,Ⅲ-Ⅴ,Ⅰ-Ⅴ peak intervals were significant?ly prolonged, and the total clinical effective rate was 88.57%. Compared with the same group before treatment and the control group af?ter treatment, the difference was statistically significant.Conclusion Acupoint injection of GM1 is safe and easy to treat in children with cerebral palsy, which is beneficial for improving clinical efficacy and is worthy of promotion. |
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