| 羊健,杨清云,孙水根,等.电压门控钠通道在慢性疼痛药物发现中的研究进展[J].安徽医药,2023,27(1):5-9. |
| 电压门控钠通道在慢性疼痛药物发现中的研究进展 |
| Research progress of voltage-gated sodium channels in drug discovery for chronic pain |
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| DOI：10.3969/j.issn.1009-6469.2023.01.002 |
| 中文关键词: 慢性疼痛 镇痛药 电压门控钠通道阻滞剂 NAV1.1电压门控钠通道 NAV1.3电压门控钠通道 NAV1.7电压门控钠通道 NAV1.8电压门控钠通道 NAV1.9电压门控钠通道 综述 |
| 英文关键词: Chronic pain Analgesics Voltage-gated sodium channel blockers NAV1.1 voltage-gated sodium channel NAV1.3 voltage-gated sodium channel NAV1.7 voltage-gated sodium channel NAV1.8 voltage-gated sodium channel NAV1.9 voltage-gated sodium channel Review |
| 基金项目:上海市科学技术委员会科研计划项目( 14401901400) |
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| 中文摘要: |
| 由于发病率高、药物效果有限或治疗药物受限等原因，慢性疼痛的治疗一直是世界范围内研究人员关注的难题。电压门控钠通道( VGSCs)阻滞剂有较为显著的镇痛作用，目前已知与慢性疼痛相关的钠通道亚型主要有 Nav1.3、Nav1.7、Nav1.8、 Nav1.9。2021年 8—9月进行了该研究，全面概括了上述钠通道亚型与慢性疼痛的关系，归纳出潜在候选药物临床前研究方法，以及已被证实安全有效的选择性钠通道阻滞剂品种，为选择性钠通道阻滞剂的开发提供参考。 |
| 英文摘要: |
| The treatment of chronic pain has always been a difficult problem concerned by researchers worldwide due to the high incidence, limited drug effects or therapeutic drugs. Voltage-gated sodium channel (VGSCs) blockers have a significant analgesic effect.Currently, the sodium channel subtypes related to chronic pain mainly include Nav1.3, Nav1.7, Nav1.8 and Nav1.9. The study was conducted from August to September 2021. This review comprehensively summarizes the relationship between the sodium channel subtypes and chronic pain, generalizes the preclinical research methods of potential drug candidates, and provides a reference for the development of selective sodium channel blockers that have been proven safe and effective. |
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