| 刘法,郝静,陈志杰.沉默信息调节因子 1、信号转导与转录激活因子 3在眼睑基底细胞癌组织中的表达及其临床意义[J].安徽医药,2023,27(1):144-147. |
| 沉默信息调节因子 1、信号转导与转录激活因子 3在眼睑基底细胞癌组织中的表达及其临床意义 |
| Expression and clinical significance of SIRT1 and STAT3 in eyelid basal cell carcinoma |
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| DOI：10.3969/j.issn.1009-6469.2023.01.032 |
| 中文关键词: |
| 英文关键词: Eyelid neoplasms Carcinoma,basal cell Silent mating-type information regulation 2 homolog 1 Signal transducer and activator of transcription 3 Proliferating cell nuclear antigen Clinicopathological classification |
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| 中文摘要: |
| 目的探讨沉默信息调节因子 1(SIRT1)和信号转导与转录激活因子 3(STAT3)在眼睑基底细胞癌组织中的表达情况及其与临床病理分类的关系。方法选取二四二医院 2014年 2月至 2017年 8月经病理证实为眼睑基底细胞癌且经手术切除保留的癌组织蜡块 93例作为观察组，皮肤基底细胞乳头状瘤组织 60例作为对照组。采用免疫组化法检测各组织中 SIRT1、STAT3蛋白阳性表达率； Spearman法分析 SIRT1和 STAT3蛋白表达相关性； χ2检验分析 SIRT1和 STAT3蛋白表达与眼睑基底细胞癌临床病理指标的联系。结果眼睑基底细胞癌组织中 SIRT1和 STAT3阳性表达率分别为 79.57%(74/93)和 76.34%(71/93)均显著高于皮肤基底细胞乳头状瘤组织( P<0.05)； Spearman法分析眼睑基底细胞癌组织中 SIRT1和 STAT3蛋白表达具有正相，关性( r= |
| 英文摘要: |
| Objective To explore the expressions of silent mating-type information regulation 2 homolog 1 (SIRT1) and signal transducer and activator of transcription 3 (STAT3) in eyelid basal cell carcinoma and their relationship with clinicopathological classification.Methods Ninety-three cases of eyelid basal cell carcinoma wax, confirmed by pathology and preserved by surgery in Harbin 242 Hospital of Aviation Industry Corporation of China from February 2014 to August 2017, were selected as observation group, and 60 cases of skinbasal cell papilloma tissues were selected as control group. Immunohistochemical method was used to detect the positive expression ratesof SIRT1 and STAT3 protein; Spearman method was used to analyze the correlation between SIRT1 and STAT3 protein expressions; chi-square test was used to analyze the relationship between SIRT1 and STAT3 protein expressions and the clinicopathological parameters ofeyelid basal cell carcinoma.Results The positive expression rates of SIRT1 and STAT3 in eyelid basal cell carcinoma were 79.57% (74/93) and 76.34% (71/93), respectively, which were significantly higher than those in basal cell papilloma (P<0.05). Spearman′s correlationanalysis showed that there was a positive correlation between SIRT1 and STAT3 protein expressions in eyelid basal cell carcinoma (r= 0.72, P<0.05). The expressions of SIRT1 and STAT3 in eyelid basal cell carcinoma were correlated with patients′ age, proliferative indexof proliferating cell nuclear antigen (PCNA), tumor size and tumor pathological type (P<0.05).Conclusions SIRT1 and STAT3 are highly expressed in eyelid basal cell carcinoma and are positively correlated. They are related to age, proliferative index of PCNA, tumor size and pathological type, which may be potential biomarkers to identify the malignant degree of eyelid basal cell carcinoma. |
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