| 李铭德,刘慧泽,张建军,等.正五聚蛋白 3、肿瘤坏死因子 -α和超敏 -C反应蛋白在妊娠期糖尿病中的预测价值分析[J].安徽医药,2023,27(1):160-163. |
| 正五聚蛋白 3、肿瘤坏死因子 -α和超敏 -C反应蛋白在妊娠期糖尿病中的预测价值分析 |
| Predictive value analysis of PTX3, TNF-α and HsCRP in gestational diabetes mellitus |
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| DOI：10.3969/j.issn.1009-6469.2023.01.035 |
| 中文关键词: 妊娠期糖尿病 正五聚蛋白 3 肿瘤坏死因子 -α 超敏 -C反应蛋白 危险因素 |
| 英文关键词: Gestational diabetes mellitus PTX3 TNF-α HsCRP Risk factors |
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| 摘要点击次数: 923 |
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| 中文摘要: |
| 目的探讨炎性因子正五聚蛋白 3(PTX3)、肿瘤坏死因子 -α(TNF-α)、和超敏 -C反应蛋白( HsCRP)单独及联合预测妊娠期糖尿病的价值。方法以 2021年 1—5月于潍坊医学院附属医院产检且妊娠 24~28周的孕妇为研究对象，将孕妇按照葡萄糖耐量试验结果分观察组( GDM组)和对照组( N-GDM组)各 40例，比较两组血清 PTX3、TNF-α、HsCRP的水平，建立受试者操作特征曲线( ROC曲线)记录曲线下面积( AUC)分析 PTX3、TNF-α、HsCRP单独及联合对 GDM的预测价值。结果 GDM组 PTX3、TNF-α、HsCRP水平要，显著高于 N-GDM组［(5，.75±0.51)μg/L比(5.11±0.56)μg/L；(19.81±1.77)ng/L比(16.68±1.81)ng/L；(4.58±3.04)mg/L比( 2.35±1.65)mg/L(均 P<0.01)］； ROC曲线结果示:血清 PTX3、TNF-α、HsCRP单独预测 GDM的 AUC分别为0.789、0.888、0.777；PTX3与 TNF-α、PTX3与 HsCRP、TNF-α与 HsCRP联合预测 GDM的 AUC分别为 0.931、0.861、0.928；三者联合预测 GDM的 AUC为 0.953；logistic回归分析炎性因子 PTX3(OR=8.92，P=0.013)、 TNF-α(OR=2.53，P<0.001)、 HsCRP(OR=2.16，P=0.013)是发生 GDM的独立危险因素。结论 GDM组血清 PTX3、TNF-α、HsCRP水平显著高于 N-GDM组，三者联合预测 GDM时 AUC达最高， PTX3、TNF-α、HsCRP是 GDM发病的独立危险因素。 |
| 英文摘要: |
| Objective To investigate the prognostic value of inflammatory factors including Pentraxin 3 (PTX3), Tumor necrosis factor-alpha (TNF-α), and high sensitivity C-reactive protein (HsCRP) alone and in combination in gestational diabetes mellitus.Meth? ods The pregnant women, who had prenatal examination in the Obstetrics Department of the Affiliated Hospital of Weifang MedicalUniversity from January 2021 to May 2021. were taken as the research objects. According to the results of glucose tolerance test, pregnant women were assigned into observation group (GDM group) and control group (N-GDM group), with 40 women in each group. The serum levels of PTX3, TNF-α and HsCRP were compared between the two groups. The receiver operating characteristic curve (ROCcurve) was established and the area under the curve (AUC) was recorded to analyze the predictive value of PTX3, TNF-α and HsCRP alone and in combination for GDM.Results The levels of PTX3 [(5.75±0.51)μg/L vs. (5.11±0.56)μg/L], TNF-α [(19.81±1.77) ng/L vs. (16.68±1.81) ng/L] and HsCRP [(4.58±3.04) mg/L vs. (2.35±1.65) mg/L] in GDM group were significantly higher than those in N-GDM group (all P<0.01). ROC curve showed that the AUCs of serum PTX3, TNF-α and HsCRP in predicting GDM were 0.789, 0.888 and 0.777, respectively. The AUCs of PTX3 and TNF-α, PTX3 and HsCRP, TNF-α and HsCRP in predicting GDM were 0.931, 0.861 and0.928, respectively. The AUC of GDM predicted by the three together was 0.953. Logistic regression analysis results showed that inflammatory factors PTX3 (OR=8.92, P=0.013), TNF-α(OR=2.53, P<0.001) and HsCRP (OR=2.16, P=0.013) were independent risk factors for GDM.Conclusions The levels of serum PTX3, TNF-α and HsCRP in GDM group were significantly higher than those in NGDM group. AUC was the highest when the three factors were combined to predict GDM, and PTX3, TNF-α and HsCRP were independent risk factors for GDM. |
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