| 徐露露,张琴,时瑞,等.南京市乙肝病人乙型肝炎病毒 P区突变特点与肝癌易感性的相关性分析[J].安徽医药,2023,27(2):277-280. |
| 南京市乙肝病人乙型肝炎病毒 P区突变特点与肝癌易感性的相关性分析 |
| The correlation between the mutation characteristics of HBV -P region and susceptibility to liver cancer in patients with hepatitis B in Nanjing |
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| DOI：10.3969/j.issn.1009-6469.2023.02.014 |
| 中文关键词: 乙型肝炎病毒 P区 突变 肝癌 易感性 |
| 英文关键词: Hepatitis B virus P region Mutation Liver cancer Susceptibility |
| 基金项目:江苏省卫生健康委员会科研项目( LGY2020015) |
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| 中文摘要: |
| 目的探讨南京市乙肝病人乙型肝炎病毒( HBV)-P区突变特点与肝癌易感性的相关性。方法选取 2018年 1月至 2020年 12月南京市第二医院乙肝病人 1 100例，所有病人均采用聚合酶链反应( PCR)检测 HBV基因分型及其 P区突变位点情况，结合病理检查明确肝癌的发生情况，分析 HBV-P区突变特点与肝癌易感性的相关性。结果结合病理检查结果，纳入的 1 100例的乙肝病人中，肝癌发生率为 2.18%(24/1 100)；肝癌组 HBV-P区突变率高于乙肝组，差异有统计学意义( P<0.05)；进一步分析 HBV-P区突变特点发现，肝癌组 rt204、rt180、rt250位点突变率高于乙肝组，差异有统计学意义( P<0.05)； logistic回归分析结果显示， rt204、rt180、rt250位点突变是乙肝病人发生肝癌易感性的独立影响因素( P<0.05)。结论南京市乙肝病人 HBV-P区突变特点与肝癌易感性有关，其中 rt204、rt180、rt250位点突变可能易导致肝癌发生。 |
| 英文摘要: |
| Objective To investigate the correlation between hepatitis B virus (HBV) -P zone mutation and hepatocellular carcino-ma (HCC) susceptibility in patients with hepatitis B in Nanjing.Methods A total of 1 100 patients with Hepatitis B from January 2018to December 2020 in Nanjing Second Hospital were selected. All patients were tested for HBV genotyping and mutation sites in P zoneby Polymerase chain reaction (PCR). The occurrence of liver cancer was determined according to pathological examination results, andthe correlation between HBV-P zone mutation characteristics and liver cancer susceptibility was analyzed.Results According to theresults of pathological examination, the incidence of liver cancer was 2.18% (24/1 100) in 1100 patients with hepatitis B.The mutationrate of HBV-P region in liver cancer group was higher than that in hepatitis B group, and the difference was statistically significant (P< 0.05);Further analysis of the mutation characteristics of HBV-P region showed that the mutation rates of rt204, rt180 and rt250 sites inliver cancer group were higher than those in hepatitis B group, and the difference was statistically significant (P<0.05);Logistic regres-sion analysis showed that rt204, rt180 and rt250 mutations were independent factors influencing the susceptibility of patients with Hep-atitis B to HCC (P<0.05).Conclusion The mutation characteristics of HBV-P region in Nanjing patients are related to the susceptibili-ty to liver cancer, among which the mutation of rt204, rt180 and rt250 sites may easily lead to the occurrence of liver cancer. |
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