| 单梦雅,钱香,朱琼,等.青年职业女性无症状高尿酸血症伴代谢失调的现况分析[J].安徽医药,2023,27(2):315-318. |
| 青年职业女性无症状高尿酸血症伴代谢失调的现况分析 |
| Analysis of the current status of asymptomatic hyperuricemia with metabolic disturbance in young professional females |
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| DOI：10.3969/j.issn.1009-6469.2023.02.023 |
| 中文关键词: 高尿酸血症 无症状疾病 青年职业女性 代谢失调 |
| 英文关键词: Hyperuricemia Asymptomatic diseases Young professional female Metabolic disturbance |
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| 中文摘要: |
| 目的分析青年职业女性无症状高尿酸血症与糖类、脂类、肾功能等代谢失调之间的关系，探讨及早控制青年职业女性血尿酸( SUA)水平的重要性。方法选取 2020年 5月至 2021年 4月在江苏省人民医院参加体检的 20~45岁青年职业女性共 29 987人，按研究对象年龄段分五组，比较不同年龄段青年职业女性的无症状高尿酸血症患病率；根据血尿酸水平分三组，比较不同等级尿酸水平者空腹血糖( FBG)、总胆固醇( TC)、三酰甘油( TG)高密度脂蛋白胆固醇( HDL-C)、低密度脂蛋白胆固醇( LDL-C)、血肌酐、血尿素异常率。结果无症状高尿酸血症总体患病率为，7.69%，5个年龄段( >20~25岁、 >25~30岁、 >30~ 35岁、 >35~40岁、 >40~45岁)无症状高尿酸血症患病率分别为 9.35%、9.03%、7.93%、7.40%、5.78%；3个 SUA组( ≤275 μmol/L、> 275~360 μmol/L、>360 μmol/L)FBG受损率分别为 0.68 %、1.49%、3.25%；高 TC率分别为 5.54%、7.39%和 11.37%；高 TG率分别为 1.43%、3.61%和 10.67%；低 HDL-C率分别为 1.97%、3.74%、7.20%；高 LDL-C率分别为 2.39%、3.79%、6.20%；高血肌酐率分别为 1.86%、4.52%和 7.94%；高血尿素率分别为 0.68%、0.86%和 1.52%。结论青年职业女性中 >20~25岁年龄段无症状高尿酸血症患病率最高， SUA水平较高者更倾向于合并代谢异常。血尿酸水平中等程度升高者代谢失调与低血尿酸水平人群有明显差异，也应引起足够重视。 |
| 英文摘要: |
| Objective To analyze the relationship between asymptomatic hyperuricemia (AHUA) and metabolic disturbance of sug-ar, lipids, and renal function and to discuss the importance of early control of serum uric acid (SUA) levels in young professional fe-males.Methods A total of 29, 987 young professional females aged 20-45 years who attended physical examinations in Jiangsu Prov-ince Hospital from May 2020 to April 2021 were selected. The prevalence of AHUA in young professional females in different agegroups was compared in five groups according to the age of the study subjects. Three groups were divided into 3 groups according to se-rum uric acid (SUA) levels. Fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), serum creatinine and blood urea abnormality rates were compared among those with different grades of uric acid levels.Results The overall incidence of AHUA was 7.69%, and the prevalence of AHUA in the 5 age groups (>20-25 years, >25-30 years, >30-35 years, >35-40 years and >40-45 years) was 9.35%, 9.03%, 7.93%, 7.40% and 5.78%, re-spectively. The impaired FBG rates in the 3 SUA groups (≤275 μmol/L, >275-360 μmol/L, and >360 μmol/L) were 0.68%, 1.49% and3.25%, respectively; high TC rates were 5.54%, 7.39% and 11.37%, respectively; high TG rates were 1.43%, 3.61% and 10.67%, re-spectively; low HDL-C rates were 1.97%, 3.74% and 7.20%, respectively; high LDL-C rates were 2.39%, 3.79% and 6.2%, respective-ly; and high creatinine rates were 1.86%, 4.52% and 7.94%, respectively; high blood urea rates were 0.68%, 0.86% and 1.52%, respec-tively.Conclusions The prevalence of AHUA in young professional females aged 20-25 years was highest, and those with higher SUAlevels were more inclined to have combined metabolic abnormalities. There was a significant difference between the metabolic distur-bance in people with moderately elevated SUA levels and those with low SUA levels, which should also be given enough attention. |
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