| 孙秋悦,曹宸,杨细虎,等.叉头框蛋白C2、淋巴管内皮透明质酸受体-1 的表达与皮肤鳞状细胞癌生物学特性的相关性[J].安徽医药,2023,27(3):457-460. |
| 叉头框蛋白C2、淋巴管内皮透明质酸受体-1 的表达与皮肤鳞状细胞癌生物学特性的相关性 |
| Correlation of the expressions of FoxC2 and LYVE-1 with biological characteristics of cutaneous squamous cell carcinoma |
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| DOI：10.3969/j.issn.1009-6469.2023.03.008 |
| 中文关键词: 皮肤肿瘤 癌，鳞状细胞 叉头框蛋白C2 微淋巴管密度 淋巴管内皮透明质酸受体-1 肿瘤转移 |
| 英文关键词: Skin neoplasms Carcinoma, squamous cell Forkhead box C2 (FoxC2) Microlymphatic vessel density(MLVD) Lymphatic vessel endothelialhyaluronan-receptor-1(LYVE-1) Tumor metastasis |
| 基金项目:国家自然科学基金项目(81641174)；江苏省卫生厅江苏省青年医学人才项目(QNRC2016841)；江苏大学附属医院博士人才启动基金项目(jdfyRC2020001) |
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| 中文摘要: |
| 目的 探讨叉头框蛋白C2(FoxC2)和淋巴管内皮透明质酸受体-1(LYVE-1)与皮肤鳞状细胞癌生物学特性的相关性。方法 收集2013年10月至2021年1月在江苏大学附属医院收治的44例原发性皮肤鳞状细胞癌病人，采用免疫组织化学染色检测FoxC2、LYVE-1的表达情况，LYVE-1的表达情况用微淋巴管密度(MLVD)表示。结果 FoxC2在皮肤鳞状细胞癌淋巴结转移组、中低分化组的高表达率［88.88%(8/9)、88.88%(16/18)］明显高于无淋巴结转移组、高分化组［42.85%(15/35)、26.92%(7/26)］(均P<0.05)。LYVE-1在皮肤鳞状细胞癌淋巴结转移组、中低分化组的表达(13.31±6.23、14.28±4.42)明显高于无淋巴结转移组、高分化组(8.67±4.33、6.39±2.09)(均P<0.05)。FoxC2、LYVE-1的表达情况与病人的年龄、性别、肿瘤长径无关(均P>0.05)。FoxC2与LYVE-1的表达呈正相关(r=0.55，P<0.01)结论 FoxC2及LYVE-1参与调控皮肤鳞状细胞癌生长及淋巴结转移，此结果为临床诊断及治疗皮肤鳞状细胞癌提供新的策略。 |
| 英文摘要: |
| Objective To investigate the relationship between forkhead box protein C2 (FoxC2) and lymphatic vessel endothelial re-ceptor 1 (LYVE-1) and the biological characteristics of cutaneous squamous cell carcinoma.Methods A total of 44 patients with pri-mary skin squamous cell carcinoma admitted to The Affiliated Hospital of Jiangsu University in Zhenjiang, Jiangsu Province from Octo-ber 2013 to January 2021 were collected. Immunohistochemical method was used to detect the expressions of FoxC2 and LYVE-1, and the expression of LYVE-1 was indicated by the microlymphatic vessel density (MLVD).Results The high expression rates of FoxC2 in the group with lymph node metastasis and the group with medium-low differentiation [88.88% (8/9), 88.88% (16/18)] were significantly higher than those in the group without lymph node metastasis and the group with high differentiation [42.85% (15/35), 26.92% (7/26)](all P<0.05). The expression levels of LYVE-1 in the group with lymph node metastasis and the group with medium-low differentiation[(13.31±6.23), (14.28±4.42)] was significantly higher than those in the group without lymph node metastasis and the group with high dif-ferentiation [(8.67±4.33), (6.39±2.09)] (all P<0.05). The expressions of FoxC2 and LYVE-1 were not related to age, gender and tumor size (all P>0.05). The expression of FoxC2 was positively correlated with the expression of LYVE-1 (r=0.55, P<0.01).Conclusions FoxC2 and LYVE-1 were involved in regulating the growth and lymph node metastasis of cutaneous squamous cell carcinoma.These re-sults provide a new strategy for clinical diagnosis and treatment of cutaneous squamous cell carcinoma. |
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