| 翁国武,刘真义.奥替溴胺联合洛哌丁胺治疗腹泻型肠易激综合征的疗效及机制分析[J].安徽医药,2017,21(1):143-146. |
| 奥替溴胺联合洛哌丁胺治疗腹泻型肠易激综合征的疗效及机制分析 |
| Efficacy of otilonium bromide combined with loperamide in the treatment of diarrhea type irritable bowel syndrome and mechanism analysis |
| 投稿时间：2016-03-11 |
| DOI： |
| 中文关键词: 奥替溴胺 洛哌丁胺 腹泻型肠易激综合征 水通道蛋白3 水通道蛋白8 |
| 英文关键词: Otilonium bromide Loperamide Irritable bowel syndrome with diarrhea Water channel protein 3 Water channel protein 8 |
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| 中文摘要: |
| 目的 观察奥替溴胺联合洛哌丁胺治疗腹泻型肠易激综合征(IBS-D)的疗效及对血清水通道蛋白-3(AQP-3)和水通道蛋白-8(AQP-8)水平的影响。方法 选择符合纳入标准的IBS-D病人共110例,按数字表法随机分为对照组和观察组,两组均55例；两组参照《肠易激综合征诊断和治疗的共识意见》给予非药物治疗；对照组给予奥替溴胺片,每次40 mg,每天3次,口服；观察组在对照组基础上给予洛哌丁胺,初始剂量2～4 mg,每天2次；两组病人均连续观察6周。比较两组腹痛、腹泻、腹胀评分及临床疗效；应用IBS生活质量问卷(IBS-QOL)量表评价两组生活质量；检测两组血清AQP-3和AQP-8水平。结果 治疗后,观察组病人的腹胀、腹泻、腹痛评分均明显低于对照组(P＜0.01)； 观察组病人治疗后总有效率为96.36％,显著高于对照组(83.02％)(P＜0.05)；观察组治疗后IBS-QOL量表评分均明显高于对照组(P＜0.01)；治疗后,观察组治疗后AQP-3和AQP-8水平明显高于对照组,差异有统计学意义(P＜0.01)。结论 奥替溴胺联合洛哌丁胺治疗IBS-D疗效明显,上调血清AQP-3和AQP-8水平可能是该疗法作用机制之一。 |
| 英文摘要: |
| Objective To investigate the efficacy of otilonium bromide combined with loperamide in the treatment of diarrhea type irritable bowel syndrome(IBS-D) and the influence on serum levels of water channel protein 3(AQP-3) and AQP-8. Methods One hundred and ten patients with IBS-D were randomly divided into control group and observation group with 55 cases in each group according to random number table.Both groups were treated with non-drug therapy according to “treatment plan of integrated Chinese and western medicine of irritable bowel syndrome”.Control group orally received otilonium bromide(40 mg,tid).Based on control group,observation group was treated with loperamide(2～4 mg,bid).Treatment course was 6 weeks for all cases.Scores of abdominal pain,diarrhea,and abdominal distension and efficacy were compared between two groups.IBS-QOL scale was used to evaluate life quality.Serum levels of AQP-3 and AQP-8 were detected in both groups. Results Scores of abdominal pain,diarrhea,and abdominal distension were obviously lower than those of control group after treatment(P＜0.01).Clinical efficacy of treatment group was 96.36 ％,which was higher than that of control groups 83.02 ％(P＜0.05).After treatment,scores of IBS-QOL and serum levels of AQP-3 and AQP-8 of observation group were remarkably higher than that of control group (P＜0.01). ConclusionEfficacy of otilonium bromide combined with loperamide in the treatment of diarrhea type irritable bowel syndrome is obvious,and can up-regulate serum levels of AQP-3 and AQP-8. |
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