| 任红军.缺血性脑卒中合并慢性肺部感染病人炎性状态变化及其对心脑血管不良事件的影响[J].安徽医药,2017,21(2):273-276. |
| 缺血性脑卒中合并慢性肺部感染病人炎性状态变化及其对心脑血管不良事件的影响 |
| The changes of inflammatory state in patients with ischemic strokecomplicated with chronic pulmonary infection and its effect oncardiovascular and cerebrovascular adverse events |
| 投稿时间：2016-02-01 |
| DOI： |
| 中文关键词: 缺血性脑卒中 慢性肺部感染 炎性状态 心脑不良事件 |
| 英文关键词: Ischemic stroke Chronic pulmonary infection Inflammatory state Cardiovascular and cerebrovascular adverse events |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨缺血性脑卒中合并慢性肺部感染病人炎性状态变化以及这些改变对心脑不良事件的影响,以期为缺血性脑卒中合并慢性肺部感染病人降低病死率提供依据。方法 选取缺血性脑卒中合并慢性肺部感染病人224例为观察组,另选取同期缺血性脑卒中病人224例为对照组,观察两组病人治疗期间慢性肺部感染急性发作或合并肺部感染发生情况、死亡情况及治疗前后炎性状态、慢性健康状况评分系统Ⅱ(ApacheⅡ)评分、神经功能缺损评分(NIHSS)、意识状态。随访1年,观察两组病人心脑血管不良事件发生情况。结果 治疗期间观察组急性肺部感染134例,死亡44例,急性肺部感染率(59.82%)及病死率(19.64%)分别高于对照组(28.13%,9.82%),差异有统计学意义(P<0.05),观察组治疗后超敏C-反应蛋白(hs-CRP)、血清降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞计数、中性粒细胞数均低于治疗前,差异有统计学意义(P<0.05),高于对照组同期(P<0.05),治疗后ApacheⅡ、NIHSS评分及意识状态低于同组治疗前(P<0.05),高于对照组同期(P<0.05)。随访期间未见失访及死亡病人,观察组脑梗死、脑出血发生率高于对照组(P<0.05),心脑血管不良事件总发生率高于对照组(P<0.05)。结论 缺血性脑卒中合并慢性肺部感染者炎性状态高于单纯缺血性脑卒中病人,预后心脑血管不良事件发生率偏高。 |
| 英文摘要: |
| Objective To investigate the changes in inflammatory status of patients with ischemic stroke complicated with chronic pulmonary infection and the effect of these changes on cardiovascular and cerebrovascular events,and to provide basis for reducing mortality in patients with ischemic stroke complicated with chronic pulmonary infection.Methods 224 patients with ischemic stroke and chronic pulmonary infection were selected as the observation group and another 224 patients with the same disease were as the control group.The incidence of acute pulmonary infection or the incidence of pulmonary infection the inflammatory status and the inflammatory status before and after treatment,the chronic health score system Ⅱ (Ⅱ) score,the neurological deficit score (NIHSS),the state of consciousness in the two groups of patients during treatment were observed.Follow-up of 1 year,the cardiovascular and cerebrovascular adverse events of the two groups were observed.Results During the treatment,in observation group it′s 134 cases of acute pulmonary infection and 44 cases of death.The acute lung infection rate (59.82%) and the mortality rate (19.64%) were significantly higher than those in the control group (28.13%,9.82%),and the differences were with statistical significance (P<0.05).The levels of high sensitivity C-reactive protein (hs-CRP),serum procalcitonin (PCT),tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),white blood cell count,and the number of neutrophils in the observation group after treatment were lower than that before treatment.The differences were with statistical significance (P<0.05),which higher than the control group of the same period(P<0.05).After treatment,the scores of ApacheⅡ and NIHSS were lower than those of the control group before treatment (P<0.05),higher than the control group of the same period(P<0.05).No losing follow-up visit and death during the follow-up.The incidence of cerebral infarction and cerebral hemorrhage in the observation group was higher than that in the control group (P<0.05).The overall incidence of cardiovascular and cerebrovascular events was higher than that of the control group (P<0.05).Conclusion The inflammatory status of ischemic stroke complicated with chronic pulmonary infection is higher than that of patients with ischemic stroke.The incidence of cardiovascular and cerebrovascular adverse events is higher. |
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