文章摘要
魏秀娟,崔晓波.白细胞介素17与喉癌侵袭转移的关联性及其预后价值[J].安徽医药,2017,21(3):465-467.
白细胞介素17与喉癌侵袭转移的关联性及其预后价值
Correlation between IL-17 and metastasis in patients with laryngeal carcinoma and its value in predicting the clinical outcomes
投稿时间:2016-08-03  
DOI:
中文关键词: 喉肿瘤  白细胞介素17  肿瘤侵润  预后
英文关键词: Laryngeal neoplasms  Interleukin-17  Neoplasm invasiveness  Prognosis
基金项目:内蒙古自治区自然科学基金项目(2014MS0856) 白细胞介素17与喉癌侵袭转移的关联性及其预后价值魏秀娟,崔晓波 (内蒙古医科大学附属医院耳鼻喉科,内蒙古自治区 呼和浩特 010050) Correlation between IL-17 and metastasis in patients with laryngeal carcinoma and its value in predicting the clinical outcomes WEI Xiujuan,CUI Xiaobo
作者单位
魏秀娟 内蒙古医科大学附属医院耳鼻喉科,内蒙古自治区 呼和浩特 010050 
崔晓波 内蒙古医科大学附属医院耳鼻喉科,内蒙古自治区 呼和浩特 010050 
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中文摘要:
      目的 探讨白细胞介素17 (Interleukin-17,IL-17)在喉癌病人中的应用价值。 方法 前瞻性收集喉癌病人50例和健康成人50例,使用ELISA法检测两组病人血清IL-17水平,并分析喉癌病人IL-17水平与其临床特征的关联性。 结果 与健康成人比较,喉癌病人IL-17水平显著升高[(63.16±19.60 )ng·L-1比(46.34±15.38)ng·L-1,t=4.774,P<0.001) ]。喉癌病人术前IL-17水平显著较术后高[ (63.16±19.60 )ng·L-1比(51.16±15.71)ng·L-1,t=3.378,P<0.001) ]。不同性别和年龄病人IL-17差异无统计学意义(P>0.05)。分化程度、TNM分期、淋巴转移、临床预后和术后复发与IL-17显著相关(P<0.01)。单因素和多因素Logistic回归分析显示TNM分期、淋巴结转移和IL-17是喉癌病人3年内死亡的影响因素(P<0.05)。 结论 血清IL-17水平与喉癌病人临床预后紧密相关,是诊断喉癌病人新的生物学指标。
英文摘要:
      Objective To investigate the clinical values of interleukin-17 (IL-17) in patients with laryngeal carcinoma. Methods Fifty cases of laryngeal cancer patients and 50 healthy adults were prospectively collected.The serum IL-17 level of the two groups was detected by ELISA and the differences were analyzed.Moreover,the correlations between IL-17 level and clinical features of patients with laryngeal cancer were studied. Results When compared with the healthy adults,patients with laryngeal cancer got a significantly higher level of IL-17 (63.16±46.34) vs.(19.60±15.38)ng·L-1,P<0.001).Preoperative IL-17 level was significantly higher than postoperative IL-17 level in patients with laryngeal cancer (63.16±19.60 )vs.(15.71±51.16)ng·L-1,P=0.001).There was no significant difference in IL-17 between patients with different gender and age (P>0.05).Differentiation degree,TNM stage,lymph node metastasis,clinical prognosis and postoperative recurrence were significantly correlated with IL-17 (P<0.01).Univariate and multivariate logistic regression analysis showed that TNM stage,lymph node metastasis and IL-17 were the influencing factors of death within 3 years in patients with laryngeal cancer (P<0.05). Conclusions The level of serum IL-17 in patients with laryngeal cancer is closely related to the clinical outcomes,and might be a new biological marker for diagnosis of laryngeal cancer.
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