| 许军,施长杲,秦汉林,等.益气养阴解毒方对晚期肝癌介入治疗减毒增效作用的临床研究[J].安徽医药,2017,21(3):541-545. |
| 益气养阴解毒方对晚期肝癌介入治疗减毒增效作用的临床研究 |
| Clinieal studies on the therapeutic effeets of combined therapy with TACE and Qi-boosting toxin-resolving granule on hepatic carcinoma |
| 投稿时间：2016-07-15 |
| DOI： |
| 中文关键词: 肝肿瘤 益气养阴 化学栓塞,治疗性 治疗结果 |
| 英文关键词: Liver neoplasms Reinforcing qi nourishing yin Chemoembolization,therapeutic Treatment outcome |
| 基金项目:安徽省中医药科学研究基金项目(2014zy33) |
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| 中文摘要: |
| 目的 观察益气养阴解毒方联合肝动脉化疗栓塞术(TACE)治疗晚期肝癌的疗效。 方法 62例原发性肝癌病人采用随机数字表法分为两组。益气养阴解毒方联合TACE手术为治疗组,共32例；单纯TACE手术为对照组,共30例。观察两组病人的近期疗效、生活质量评分、病人免疫功能和肝功能指标变化情况；随访两组病人2年,对病人半年、1年、2年生存率进行统计、比较。 结果 治疗组32例病人中,完全缓解8例,部分缓解17例,治疗组总有效率达78.1%与对照组的56.7%比较,Uc＝1.936,P＝0.053； 治疗组病人治疗后时间段的KPS评分明显优于对照组(P＜0.05)；两组病人的外周血白细胞(WBC) 、T细胞亚群(CD4 /CD8、CD+4 、CD+3)、自然杀伤细胞(NK) 水平均差异有统计学意义(P＜0.05)；在肝功能指标方面,治疗组血清总胆红素( TBil ) 、谷丙转氨酶(ALT)、谷草转氨酶(AST)指标较对照组改善明显(P＜0.05);治疗组1、2 年生存率分别为67.65%、36.74%,高于对照组的37.38%、10.10%,经Logrank检验差异有统计学意义(P＜0.05)。 结论 益气养阴解毒方联合TACE治疗原发性肝癌在改善生活质量、保护肝功能及延长病人者生存期方面优于单纯TACE。 |
| 英文摘要: |
| Objective To observe the clinical effects of Qi-boosting toxin- resolving granule combined with TACE for the treatment of advanced primary hepatic carcinoma. Methods 62 patients with advanced primary hepatic carcinoma were randomly divided into two groups,the observation group (Qi-boosting toxin- resolving granule combined with TACE) with 32 cases,the control group (conventional TACE alone) with 30 cases.The size of tumor thrombus,the quality of life and the peripheral blood index of laboratory were observed before and after treatment.The follow-up lasted 6 to 24 months,and the survival rate was calculated. Results Among the 32 cases of patients in treatment group,the complete remission is 8 cases,partial response is 17 cases,compared the treatment group total effective rate of 78.1% with 56.7% in the control group,Uc = 1.936,P=0.053.KPS score of patients in treatment group after treatment was improved more significantly than that of control group(P＜0.05).peripheral blood indexes,such as WBC,CD4 / CD8, CD+ 4,CD+ 3,NK among two groups of patients were statistically significant difference (P<0.05).the liver function such as TBIL and AIT were lower thanthose of the control group (P<0.05).The survival rate of 1 year and 2 year in the treatment group was 67.65% and 36.74%,respectively,which was higher than that of the control group (37.38%and 10.10%),and the difference was statistically significant by LOGRANK test (P<0.05). Conclusions Qi-boosting toxin- resolving granule combined with TACE in treatmenting primary hepatic carcinoma was better than conventional TACE alone in improving the quality of life,protect the liver function and prolong the survival period in patients. |
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