| 王旭东.小柴胡汤治疗慢性肾小球肾炎24例[J].安徽医药,2017,21(3):546-549. |
| 小柴胡汤治疗慢性肾小球肾炎24例 |
| Xiaochaihu Decoction for treating chronic kidney diseases |
| 投稿时间：2016-05-30 |
| DOI： |
| 中文关键词: 肾小球肾炎 小柴胡汤 和解少阳 医学,中国传统 |
| 英文关键词: Glomerulonephritis Xiaochaihu decoction Reconciliating shaoyang Medicine,chinese traditional |
| 基金项目: |
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| 摘要点击次数: 2097 |
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| 中文摘要: |
| 目的 观察小柴胡汤和解少阳法治疗慢性肾小球肾炎的机制及临床疗效。 方法 将48例慢性肾小球肾炎少阳病病人随机数字表法分为治疗组(小柴胡汤治疗组)和对照组(常规治疗组),每组24例,治疗组是在常规治疗的基础上给予小柴胡汤。治疗5周以后,对比观察两组中医证候、疾病疗效、24 h尿蛋白定量、肾功能、外周血干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)、T细胞1型/2型(Th1/Th2)、白细胞介素-17(IL-17)的变化情况。 结果 两组病人经治疗后,治疗组各中医症候改善情况显著优于对照组(P＜0.05),且其总有效率(75.0%)与对照组(45.8%)相比有显著提升,差异有统计学意义(P=0.039)；治疗组尿蛋白24 h定量(1.33±0.90) g较对照组(1.83±0.96) g差异无统计学意义(P=0.07)；治疗组治疗后外周血上述各项指标改善程度显著优于治疗前(P<0.05),而对照组治疗前后差异无统计学意义(P>0.05),组间对比,治疗后IFN-γ、IL-4、IL-17差异无统计学意义(P>0.05),Th1/Th2治疗组(0.73±0.49)较对照组(1.96±2.27)差异有统计学意义(P<0.05);另两组肾功能指标尿素氮、肌酐、肾小球率过率改善情况差异无统计学意义(P>0.05)。 结论 小柴胡汤可以通过调节病人免疫状态,改善炎性反应,从而起到减轻尿蛋白,治疗慢性肾小球肾炎的作用。 |
| 英文摘要: |
| Objective To observe mechanism and clinical efficacy of Xiaochaihu Decoction for treating chronic kidney diseases(CKD) according to the theory of harmonizing Shaoyang. Methods The 48 CKD patients with Shaoyang disease were randomly assigned to two groups,the treatment group (treated by Xiaochaihu Decoction) and the control group (the conventional therapy group),24 in each group.Respectively 5 weeks after treatment,the changes of the effectiveness,Chinese medical syndrome,24h urinary protein,renal function,the peripheral blood IFN-γ,IL-4,Th1/Th2 and IL17 were compared. Results After treatment,the improvement of the effectiveness ,Chinese medical syndrome was better in the treatment group(P＜0.05).The total effective rate (75.0%) was significantly higher than 45.8% in the control group (P=0.039).The 24 h urinary protein (1.33±0.90) g was not significantly different from (1.83±0.96)g in the control group (P=0.07).The improvement of peripheral blood indexes mentioned above for treatment group after treatment was superior to that before treatment(P＜0.05),but there was no significant difference in the control group between pretreatment and posttreatment (P>0.05).There were no significant different between two groups in IFN-γ,IL-4,and IL-17 (P>0.05),while Th1/Th2 in treatment group was significantly different from that in control group [(0.73±0.49) vs(1.96±2.27),P<0.05].There were no significant differences in the improvements of Bun,Scr and GFR between two groups(P>0.05). Conclusions Xiaochaihu Decoction could be used to treat CKD,relieve the proteinuria by the immunoregulation and improvement of inflammation. |
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