| 黄伟,黄翔,方量.益气止血方联合质子泵抑制剂治疗非静脉曲张性上消化道出血的疗效观察[J].安徽医药,2017,21(3):554-557. |
| 益气止血方联合质子泵抑制剂治疗非静脉曲张性上消化道出血的疗效观察 |
| Efficacy of Yiqihuoxuefang combined with proton pump inhibitor on the treatment of non-variceal upper gastrointestinal bleeding |
| 投稿时间：2016-08-15 |
| DOI： |
| 中文关键词: 胃肠出血 医学,中国传统 补气 止血 质子泵抑制剂 |
| 英文关键词: Gastrointestinal hemorrhage Medicine,chinese traditional Reinforcing qi Hemostasis Proton pump inhibitors |
| 基金项目: |
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| 中文摘要: |
| 目的 观察益气止血方联合质子泵抑制剂治疗轻、中度非静脉曲张性上消化道出血(ANVUGIB)的效果。 方法 确诊为轻、中度ANVUGIB的病人100例,随机数字表法分为两组。对照组(n=50例)给予质子泵抑制剂进行止血治疗,观察组(n=50例)给予益气止血方联合质子泵抑制剂进行止血治疗。观察治疗过程中两组病人平均出血量、平均输血量和完全止血时间、治疗前后胃管引流液pH值和血红蛋白和治疗后两组病人的治疗效果以及治疗过程中不良反应情况。 结果 ①观察组病人的平均出血量、平均输血量和平均止血时间分别为(239.16±20.15)mL、(467.31±34.97)mL、(22.09±2.73)h均优于对照组[(408.35±30.94)mL、(825.64±50.82)mL、(31.24±3.46)h],差异有统计学意义(t=32.401、41.073、14.680,P=0.000、0.000、0.005)。②观察组病人治疗后胃管引流液pH值为(6.53±0.50),高于对照组(5.79±0.47),差异有统计学意义(t=7.625,P=0.041)；观察组治疗后血红蛋白值为(104.97±5.04)g·L-1,高于对照组(95.72±4.86)g·L-1,差异有统计学意义(t=9.342,P=0.037)。③观察组病人治疗后总有效率为90.00%,显著高于对照组70.00%(χ2 ＝6.250,P＝0.043)。④观察组治疗过程中不良反应比例为12.00%,显著低于对照组32.00%(χ2 ＝5.828,P＝0.045)。 结论 益气止血方联合质子泵抑制剂可减少轻、中度ANVUGIB病人的出血量,控制病人出血时间,优化病人胃管引流液pH值,同时降低治疗后再出血等不良反应的发生率,联合用药的止血效果优于单独用药。 |
| 英文摘要: |
| Objective To observe the efficacy of yiqihuoxuefang combined with proton pump inhibitor on the treatment of non-variceal upper gastrointestinal bleeding. Methods One hundred cases diagnosed with non-variceal upper gastrointestinal bleeding from January 2013-January 2015 were randomized assigned into two groups according to random number table method.The control group (n=50) was treated with proton pump inhibitors hemostasis,and the observation group (n=50) was given yiqihuoxuefang combined with proton pump inhibitors hemostasis.To analysis the differences of the average amount of bleeding,average amount of blood transfusion,average time to hemostasis,tube drainage fluid pH value,hemoglobin,treatment effect and adverse reactions in the two groups. Results ①After treatment,the average amount of bleeding,average amount of blood transfusion,average time to hemostasis of the observation group were (239.16 ± 20.15)mL,(467.31 ± 34.97)mL,(22.09 ± 2.73)h,better than the control group[ (408.35 ± 30.94)mL,(825.64 ± 50.82)mL,(31.24 ± 3.46)h],and the differences were statistically significant(t=32.401,1.073,4.680,P=0.000,0.000,0.005).②After treatment,the tube drainage fluid pH value of the observation group was (6.53 ± 0.50),better than the control group (5.79 ± 0.47),and the difference was significant(t=7.625,P=0.041).The hemoglobin level of the observation group was (104.97 ± 5.04)g·L-1,better than the control group (95.72 ± 4.86)g·L-1,and the difference was significant(t=9.342,P=0.037).③After treatment,the total effective rate of the observation group was 90.00%,significantly higher than the control group with 70.00%,(χ2＝6.250,P＝0.043).④During treatment,the adverse reactions of the observation group was 12.00%,significantly lower than the control group with 32.00%(χ2＝5.828,P＝0.045). Conclusions The yiqihuoxuefang combined with proton pump inhibitors can reduce the amount of bleeding of upper gastrointestinal bleeding in patients with non-variceal,control bleeding time,optimize tube drainage fluid pH value,During treatment,it can reduce the adverse reactions rate,the effect of combination therapy is superior than monotherapy. |
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