文章摘要
袁继福,刘丽娟.连续性血液净化治疗全身炎性反应综合征的效果及对机体免疫功能的影响[J].安徽医药,2017,21(4):679-682.
连续性血液净化治疗全身炎性反应综合征的效果及对机体免疫功能的影响
Effect of CBP on the treatment of SIRS and its influence on the immune function of the body
投稿时间:2016-07-15  
DOI:
中文关键词: 连续性血液净化  全身炎性反应综合征  免疫功能
英文关键词: Continuous blood purification  Systemic inflammatory response syndrome  Immune function
基金项目:
作者单位
袁继福 汉中市铁路中心医院肾脏内科,陕西 汉中 723000 
刘丽娟 汉中市铁路中心医院肾脏内科,陕西 汉中 723000 
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中文摘要:
      目的 探讨连续性血液净化(CBP)治疗全身炎性反应综合征(SIRS)的效果及对机体免疫功能的影响。方法 全身炎性反应综合征(SIRS)病人80例,根据其治疗方式分为对照组和观察组,其中对照组48例,观察组32例,对照组采用常规治疗,观察组在常规治疗的基础上给予连续性血液净化治疗(CBP)。观察两组病人的治疗效果,比较两组病人治疗前后炎性细胞因子水平、免疫指标和肾功能指标的差异。结果 治疗手段是影响有效率的因素;观察组治疗的总有效率为96.88%,明显高于对照组(79.17%),差异有统计学意义(P<0.05);治疗前两组病人白细胞介素-10(IL-10)、白细胞介素-13(IL-13)和白介素-12(IL-12)等炎性细胞因子水平无明显差别,治疗后,两组病人的上述指标均降低,且观察组降低更明显(P<0.05);两组病人治疗前免疫球蛋白G(IgG)、免疫球蛋白A(IgA)和免疫球蛋白M(IgM)水平无明显差别,治疗后,两组病人的上述指标均较治疗前增高,且观察组增高明显;两组病人治疗前的谷丙转氨酶(ALT)、谷草转氨酶(AST)等肝肾功能指标无明显差异,治疗后,两组病人的上述指标水平均较治疗前降低,且观察组下降更明显(P<0.05)。结论 连续性血液净化对SIRS病人有较好的治疗效果,可明显减轻机体炎性反应,提高病人的免疫功能,具有推广应用的价值。
英文摘要:
      Objective To investigate the effect of continuous blood purification (CBP) on systemic inflammatory response syndrome (SIRS) and its effect on the immune function of the body.Methods Eighty systemic inflammatory response syndrome (SIRS) patients were selected as subjects.The patients were assigned into control group (48 cases) and observation group (32 cases) according to their therapies.The control group used conventional treatment while the observation group adopted continuous blood purification (CBP) treatment on the basis of routine therapy.The therapeutic effects of the two groups were observed and the levels of inflammatory cytokines,immune indexes and renal function indexes were compared before and after the treatment.Results Treatment was a factor that affected the efficiency of the treatment.The total effective rate in observation group was 96.88%,significantly higher than the control group (79.17%);the difference was statistically significant (P<0.05).The levels of interleukin-10 (IL-10),interleukin-13 (IL-13) and Interleukin-12 (IL-12) in the two groups had no significant difference before treatment,while after treatment,the above indexes of the two groups of patients were both lower,which decreased more obviously in the observation group (P<0.05).The levels of IgG,IgA and IgM in the two groups had no significant difference before treatment,while after treatment,the indexes of the two groups were higher than those before treatment,which increased significantly in the observation group.The levels of liver and kidney function indexes in the two groups,including ALT,AST,had no significant difference,while after treatment,the indexes of the two groups were lower than those before treatment,which decreased more significantly in the observation group (P<0.05).Conclusions Continuous blood purification achieves good effects on SIRS patients,which can significantly reduce the body′s inflammatory response and improve the patient′s immune function.It has the value of popularization and application.
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