| 王发,周志云,刘雪峰,等.高效液相色谱法测定复方枇杷喷托维林颗粒中枸橼酸喷托维林的含量[J].安徽医药,2017,21(5):828-830. |
| 高效液相色谱法测定复方枇杷喷托维林颗粒中枸橼酸喷托维林的含量 |
| Simultaneous determinationof pentoryverine citrate in CompoundLoquat and Pentoryverine Granules by HPLC |
| 投稿时间：2016-09-04 |
| DOI： |
| 中文关键词: 高效液相色谱法 复方枇杷喷托维林颗粒 枸橼酸喷托维林 |
| 英文关键词: |
| 基金项目:国家药典委员会2015年标准提高研究项目(104) 作者简介:王发,男,副主任药师,研究方向:药品、食品的分析检验和药品质量标准提高,E-mail:wangf1974@126.com高效液相色谱法测定复方枇杷喷托维林颗粒中枸橼酸喷托维林的含量王发,周志云,刘雪峰,罗世书 (陕西省食品药品检验所,陕西 西安 710061)高效液相色谱法测定复方枇杷喷托维林颗粒中枸橼酸喷托维林的含量 王发,周志云,刘雪峰,罗世书 Simultaneous determinationof pentoryverine citrate in CompoundLoquat and Pentoryverine Granules by HPLC WANG Fa,ZHOU Zhiyun,LIU Xuefeng,LUO Shishu |
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| 中文摘要: |
| 目的 建立复方枇杷喷托维林颗粒中枸橼酸喷托维林含量的高效液相测定方法。方法 采用Aglient C18(150 mm×4.6 mm,5 μm)色谱柱；流动相:1%三乙胺溶液(用磷酸调pH至3.0 )-乙腈(70∶30)；流速:1.0 mL·min-1；检测波长:210 nm。结果 枸橼酸喷托维林在0.02～1.01 g·L-1的质量浓度范围内线性关系良好,Y=6 652 832.11 X-8 399.71(r=0.999 9),平均加样回收率为99.4%,RSD＝1.2%。结论 该法简便、准确,可用于复方枇杷喷托维林颗粒中枸橼酸喷托维林的质量控制。 |
| 英文摘要: |
| Objective To establish a HPLC method for the determination of pentoryverine citrate in Compound Loquat and Pentoryverine Granules.Methods The chromatorgraphic conditions were as follows:Aglient C18 (150 mm×4.6 mm,5 μm)column was used.1%triethylamine(pH 3.0)-acetonitrile(70∶30) was used as mobile phase,and the flow rate was at 1.0 mL·min-1.The detect wavelength was at 210 nm,the column temperature was 35 ℃.Results Thecalibration curves were linearly in the range of 0.02-1.01 g·L-1,the regression equation was Y=6 652 832.11 X-8 399.71(r=0.999 9).The average recover was 99.4%.Conclusion The method was simple,accurateand can be used for quality control. |
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