| 狄子晖.血浆炎性因子及抗糜蛋白酶水平与迟发型阿尔茨海默病的相关性分析[J].安徽医药,2017,21(5):863-865. |
| 血浆炎性因子及抗糜蛋白酶水平与迟发型阿尔茨海默病的相关性分析 |
| Correlation of plasma level of inflammatory factorandantichymotrypsin with late onset Alzheimer′s disease |
| 投稿时间：2016-09-19 |
| DOI： |
| 中文关键词: 白细胞介素-1β 白细胞介素-6 肿瘤坏死因子-α 抗糜蛋白酶 迟发型阿尔茨海默病 |
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| 中文摘要: |
| 目的 观察和探讨血浆中白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和抗糜蛋白酶(ACT)水平与迟发型阿尔茨海默病(AD)的相关性与临床意义。方法 选择收治的迟发型AD病人组50例,另选取50例健康老年者作为对照组。采用双抗体夹心酶联免疫吸附试验(DAS-ELISA)方法检测血浆IL-1β、IL-6、TNF-α和ACT水平。比较两组血浆中IL-1β、IL-6、TNF-α和ACT水平,分析上述指标与迟发型AD的相关性。结果 与对照组血浆中IL-1β和IL-6水平(30.25±5.86)ng·L-1、(74.61±45.93)ng·L-1比较,迟发型AD 组血浆中IL-1β和IL-6水平明显增高至(41.28±5.96)ng·L-1、(176.53±49.27)ng·L-1,均差异有统计学意义(P<0.01)。与对照组TNF-α和ACT水平(35.94±7.83)ng·L-1、(220.74±36.53)ng·L-1比较,迟发型AD 组血浆中TNF-α和ACT水平明显增加至(61.28±5.16)ng·L-1、(243.85±40.74)ng·L-1,均差异有统计学意义(P<0.01)。IL-1β、IL-6、TNF-α和ACT含量随痴呆的加重呈增高的趋势,不同严重程度AD组间IL-1β、TNF-α和ACT含量差异有统计学意义(P<0.05)。结论 AD病人血浆IL-1β、IL-6、TNF-α和ACT水平检测可作为临床辅助诊断迟发型AD的生物学指标,可能影响迟发型AD的发病进展。 |
| 英文摘要: |
| Objective To observe and discuss the correlation and clinical significance of plasma interleukin-1β (IL-1β),interleukin-6(IL-6),tumour necrosis factor-α (TNF-α) and antichymotrypsin (ACT) with late onset Alzheimer′s disease (AD).Methods Fifty cases of late onset AD patients treated from December 2014 to March 2016 in Hospital of China Aerospace Center were selected as late onset AD group,and another 50 healthy elderly patients as control group.The plasma IL-1β,IL-6,TNF-α and ACT were detected by using Double antibody sandwich enzyme-linked immunosorbent assay(DAS-ELISA) method and compared for the analysis of the correlation of the above indexes and late onset Alzheimer′s disease.Results Compared with plasma IL-1β and IL-6 levels of control group [(30.25±5.86)、(74.61±45.93) ng·L-1],plasma IL-1β and IL-6 levels of late onset AD group were significantly higher [(41.28±5.96)、(176.53±49.27) ng·L-1].The comparative differences were statistically significant (P<0.01).Compared with plasma TNF-α and ACT levels of the control group[(35.94±7.83)、(220.74±36.53) ng·L-1],plasma TNF-α and ACT levels of late onset AD group were obviously increased [(61.28±5.16)、(243.85±40.74) ng·L-1].The differences were statistically significant (P<0.01).The plasma IL-1β,IL-6,TNF-α and ACT tended to increase with the increase of dementia degrees.There were significant differences in IL-1β,TNF-α and ACT among AD groups with different severity (P<0.05).Conclusions The plasma IL-1β,IL-6,TNF-α and ACT can be adopted as biological indicators in clinical auxiliary diagnosis for patients with AD,the detection of which can affect the pathogenesis progress for late onset AD patients. |
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