文章摘要
孙思雨,马涛.非那沙星眼用温敏凝胶的家兔眼刺激性试验及药效学研究[J].安徽医药,2017,21(6):998-1000.
非那沙星眼用温敏凝胶的家兔眼刺激性试验及药效学研究
The eye irritation test and pharmacodynamic study in rabbits of finafloxacin thermosensitive gel for eyedropSUN Siyu,MA Tao (Department of Pharmacy,The Second Affiliated Hospital of Bengbu Medical College, Bengbu,Anhui 233000,China) Abstract:Objective
投稿时间:2016-08-24  
DOI:
中文关键词: 非那沙星  温度敏感型原位凝胶  家兔  刺激性  药效学
英文关键词: Finafloxacin  Thermosensitive gel  Rabbit  Irritation  Pharmacodynamic
基金项目:
作者单位
孙思雨 蚌埠医学院第二附属医院药剂科,安徽 蚌埠 233000 
马涛 蚌埠医学院第二附属医院药剂科,安徽 蚌埠 233000 
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中文摘要:
      目的 研究非那沙星眼用温度敏感型原位凝胶(FTGE)对兔眼刺激性及药效学。 方法 用Draize兔眼刺激性实验考察FTGE的眼部刺激性;以大肠杆菌及金黄色葡萄球菌感染的兔用FTGE进行局部治疗,观察其经过治疗后的细菌清除率。 结果 FTGE无明显刺激性,符合眼用制剂的要求;FTGE的细菌清除率超过80%,药效优于氧氟沙星滴眼液。 结论 FTGE在实验中无明显刺激性,且治疗角膜炎临床疗效明显,可供临床使用。
英文摘要:
      Objective To study the eye irritation test and pharmacodynamic study of Finafloxacin Thermosensitive Gel for Eyedrop (FTGE) in rabbits. Methods Per-Draize technique for eye irritation test in rabbits was used in the experiment.Infecting the rabbit′s eye with staphylococcus aureus and Escherichia coli and make treatment of local medication with FTGE.The bacterial clearance were observed after treated. Results The FTGE had no significant irritation and correspond with the requirements for ophthalmic preparations.The bacterial clearance rate exceeded 80 %,and its efficiency was better than ofloxacin eye drops. Conclusion The FTGE had no significant irritation and the curative effect was good of keratitis,so it is useful to clinical treatment.
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