| 惠灿灿,孙建然,许敏,等.不孕症病人血清白细胞介素-6和甲状腺功能的相关性研究[J].安徽医药,2017,21(6):1026-1029. |
| 不孕症病人血清白细胞介素-6和甲状腺功能的相关性研究 |
| Serum level of interleukin-6 in infertility patients and its relationship with thyroid function |
| 投稿时间：2016-12-23 |
| DOI： |
| 中文关键词: 不孕症 甲状腺功能减退 白细胞介素-6 |
| 英文关键词: Infertility Hypothyroidism Interleukin-6 |
| 基金项目:安徽省自然科学基金项目(1608085MH207)；安徽省高等学校省级自然科学研究项目(KJ2013Z112) |
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| 中文摘要: |
| 目的 了解不孕症病人血清白细胞介素-6(IL-6)的水平及其与甲状腺功能的相关性。方法 选取66例不孕症女性为不孕组,根据其血清甲状腺激素水平将其分为不孕合并甲状腺功能减退组(32例)和不孕未合并甲状腺功能减退组(34例),另外选取健康孕龄期妇女29例为对照组,分别测定三组血清中IL-6、甲状腺激素及甲状腺自身抗体的水平。结果 (1)与对照组相比,不孕组病人血清IL-6水平升高(P<0.01)；(2)在不孕症病人中,不孕合并甲减病人较不孕未合并甲减病人血清IL-6水平升高(P<0.01)；(3)不孕症女性中,血清抗甲状腺球蛋白抗体(ATG)、抗甲状腺过氧化物酶抗体(TPO-Ab)阳性病人较阴性病人血清IL-6水平升高(P<0.01)；(4)不孕症病人血清IL-6水平与游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、ATG、TPO-Ab均呈线性相关(P<0.01)。多元线性回归分析调整混杂因素后,IL-6与FT3、FT4的相关性更为显著(P<0.05)。结论 不孕症病人血清IL-6水平升高,尤其在合并甲减时更为明显,提示IL-6与甲状腺激素水平有一定的相关性。同时,甲状腺自身抗体阳性的不孕症病人也可通过影响IL-6的水平参与不孕症的发生发展。 |
| 英文摘要: |
| Objective To study the serum interleukin-6 (IL-6) level of infertility patients and its association with thyroid function.Methods 66 female patients with infertile were selected as research subjects,which were divided into two groups according to serum thyroid hormones level:infertile women with hypothyroidism and without hypothyroidism.Another 29 healthy women in reproductive age in our hospital were chosen as control group.The concentrations of IL-6,thyroid hormones,thyroid autoantibodies were detected respectively.Results Compared to the control group,the infertility group had higher level of IL-6(P<0.01).The IL-6 level in infertility patients with hypothyroidism was higher than that in infertility patients without hypothyroidism(P<0.01).In infertility patients,the IL-6 levels in ATG-positive or TPO-Ab positive group were higher than that in the ATG-negative or TPOAb-negative group,the difference was statistically significant (P<0.01).There were linear correlation between IL-6 and free triiodothyronine (FT3),free fhyroxine (FT4),thyroid-stimulating hormone (TSH),antithyroglobulin antibody (ATG) and thyroid peroxidase antibody(TPO-Ab) in infertility patients (P<0.01).The IL-6 levels were still significantly correlated with FT3,FT4,even after adjustment of confounding factors with multiple linear regression analysis.Conclusions The elevated serum levels of IL-6 exist in infertility patients,especially among women with hypothyroidism,which suggest the relationship between IL-6 and thyroid hormones.Thyroid autoantibodies affect the development of infertility through its influence on IL-6. |
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