| 徐万洲,吴青,李艳,等.湖北地区女性人乳头瘤病毒基因分型检测的临床意义[J].安徽医药,2017,21(6):1030-1033. |
| 湖北地区女性人乳头瘤病毒基因分型检测的临床意义 |
| Clinical significance of human papillomavirus genotyping in female lived in hubei province |
| 投稿时间：2016-12-18 |
| DOI： |
| 中文关键词: 人乳头瘤病毒 基因分型 流行病学 宫颈癌 |
| 英文关键词: Human papillomavirus Genotyping Prevalence Cervical cancer |
| 基金项目: |
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| 摘要点击次数: 2475 |
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| 中文摘要: |
| 目的 调查湖北地区女性高危型人乳头瘤病毒(HPV)的感染情况,评估HPV基因分型检测在临床检测中的意义,为湖北地区宫颈癌预防筛查提供依据。方法 回顾性分析武汉大学人民医院门诊和体检中检测HPV病毒分型的结果,分别统计其感染率,各年龄段的感染率、感染基因型及各基因型的检出率,以及感染模式等。结果 进行HPV基因分型检测的总人数为9 085例,感染率为21.23%(1 929/9 085),共检出27种基因型,高危型和低危型检出率分别为16.93%(1 538/9 085)和5.15%(468/9 085),HPV感染以单一型感染为主,占比高达80.97%。阳性率最高的三种基因型分别是HPV 16型(3.85%),HPV 52型(3.37%) 和 HPV 58型(2.59%),按年龄分为<30岁,30～＜40岁,40～＜50岁,50～＜60岁,≥60岁共5组,各年龄段的感染率分别为27.40%、22.95%、18.44%、20.54%、14.98%,组间差异有统计学意义(χ2=66.05,P<0.05)；各年龄组中高危型占比分别为79.04%(415/525)、81.49%(559/686)、75.70%(539/712)、75.30%(250/332)、73.71%(68/92),差异有统计学意义(χ2=9.60,P<0.05)。结论 湖北地区HPV感染率为21.23%,不同年龄段HPV感染率差异有统计学意义,随年龄增长感染率有下降趋势,且高危型病毒感染率随年龄增大而降低,且以单一型感染为主,HPV基因分型检测对发现宫颈癌癌前病变和宫颈癌的预防有重要意义。 |
| 英文摘要: |
| Objective To investigate the infection of human papillomavirus (HPV) in female in Hubei Province and evaluate the significance of HPV genotyping on clinical detection and provide epidemiological evidence for the prevention and screening of cervical cancer.Method HPV testing results were retrospectively analyzed.All testing were performed by the Tellgenplex HPV DNA Test.Overall prevalence,age-specific prevalence,genotype distributions and infection pattern were analyzed.Result A total of 9 085 samples were tested and the overall HPV prevalence was 21.23%(1 929/9 085).Twenty seven genotypes were detected with 16.93%(1 538/9 085) positive for high risk HPV (HR-HPV) and 5.15%(468/9 085) positive for low risk HPV (LR-HPV).80.97% of HPV positive cases were positive for single HPV type.The three most common HPV types detected were HPV 16 (3.85%),HPV 52 (3.37%) and HPV 58 (2.59%).All of the cases were divided into five age groups:<30 years,30-＜40 years,40-＜50 years,50-＜60 years and ≥60 years old,and the HPV positive rate of each group were 27.40%,22.95%,18.44%,20.54% and 14.98% respectively.The differences among the five groups had statistical significance(χ2=66.05,P<0.05).The high risk HPV infected patients account 79.04%(415/525),81.49%(559/686),75.70%(539/712),75.30%(250/332) and 73.71%(68/92) respectively in the positive patients of different age groups,and their differences also had statistical significance (χ2= 9.60,P<0.05).Conclusion The HPV positive rate in female of Hubei province was 21.23%.The age-specific prevalence and genotype distribution of HPV were different in different age groups.The positive rate and high-risk proportion decreased with age. |
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