| 施姗姗,闵旭红.食管鳞癌适形调强放疗相关血液毒性的影响因素分析[J].安徽医药,2017,21(6):1040-1044. |
| 食管鳞癌适形调强放疗相关血液毒性的影响因素分析 |
| The analysis of hematologic toxicity in intensity modulated radiation therapy for esophageal squamous cell carcinoma |
| 投稿时间：2016-09-13 |
| DOI： |
| 中文关键词: 食管鳞癌 适形调强放疗 骨髓抑制 影响因素 |
| 英文关键词: Esophageal squamous cell carcinoma Intensity modulated radiation therapy Intensity modulated radiation therapy Factors |
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| 中文摘要: |
| 探讨食管鳞癌病人适形调强放疗相关血液毒性的影响因素。方法 回顾性分析66例食管鳞癌病人接受放疗后的血常规变化情况,根据美国国立癌症研究所毒性标准将骨髓抑制程度分为正常(0度)、轻度(Ⅰ度和Ⅱ度)和重度(Ⅲ度和Ⅳ度),研究性别、年龄、血清白蛋白、体质量指数、胸骨受量、是否手术、是否同步化疗等因素对血液毒性的影响。 结果 白细胞、血红蛋白和血小板下降的发生率分别为87.9%(58/66)、28.8%(19/66)、57.6%(38/66),其中重度骨髓抑制白细胞、血红蛋白、血小板下降的发生率分别为25.8%(17/66)、1.5%(1/66)、15.1%(10/66)。分析显示性别、年龄、血清白蛋白水平、是否手术对骨髓抑制的影响差异无统计学意义(P＞0.05),体质量指数、胸骨受量、是否同步化疗对骨髓抑制的影响差异有统计学意义(P＜0.05)。 结论 食管鳞癌病人放疗过程中出现急性血液毒性比例较高,体质量指数低、胸骨受量高、接受同步化疗增加重度血液毒性发生的概率,合理评估病人状况、优化放疗方案、动态监测血常规可以降低和及时处理重度血液毒性。 |
| 英文摘要: |
| Objective To explore the influence factors of hematologic toxicityin intensity modulated radiation therapy for esophageal squamous cell carcinoma. Methods We retrospectively compared the blood-routine changes in 66 cases of esophageal squamous cell carcinoma underwent intensity modulated radiation therapy.Patients were divided into normal group,middle surppression group and sever suppression group according to toxicity standards of National Cancer Institute.Factors such as gender,age,serum albumin,body mass index,sternal irradiated dose,operation and chemotherapy were analyzed. Results The incidence of hematologic toxicity in leucopenia,hemoglob and thrombo were 87.9%(58/66),28.8%(19/66),57.6%(38/66) respectively.Severe suppression of them were 25.8%(17/66),1.5%(1/66),15.1%(10/66).Body mass index,sternal irradiated dose and chemotherapy were correlated with hematologic toxicity. Conclusion Hematologic toxicity is normal in intensity modulated radiation therapy for esophageal squamous cell.Lower body mass index,high sternal irradiated dose and synchronous chemotherapy can increase hematologic toxicity.Severe suppression of hematologic toxicity can be decreased by reasonable accessing patients’ condition and optimizing radiotherapy treatment. |
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