| 黄金平,吴屹哲,华杜鹃.头孢哌酮舒巴坦/他唑巴坦致肾衰竭病人抽搐12例临床分析[J].安徽医药,2017,21(6):1154-1156. |
| 头孢哌酮舒巴坦/他唑巴坦致肾衰竭病人抽搐12例临床分析 |
| Clinical analysis of the convulsion caused by cefoperazone-sulbactam/tazobactam in patients with renal failure |
| 投稿时间：2016-08-03 |
| DOI： |
| 中文关键词: 头孢哌酮 舒巴坦 他唑巴坦 肾衰竭 抽搐 |
| 英文关键词: Cefoperazone Sulbactam Tazobactam Renal failure Convulsion |
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| 中文摘要: |
| 目的 探讨头哌酮舒巴坦/他唑巴坦致肾衰竭病人抽搐的临床特点,并分析其原因。方法 回顾性分析住院期间12例使用头孢哌酮舒巴坦/他唑巴坦后发生抽搐的肾衰竭病人的临床表现、抽搐发作与药物使用时间的关系及治疗,初步分析头孢哌酮舒巴坦/他唑巴坦导致肾衰竭病人抽搐原因。结果 3例病人在使用头孢哌酮舒巴坦/他唑巴坦3～10 d后出现抽搐,9例病人在用药7～14 d的疗程结束后2～8 d出现抽搐,且均伴有意识丧失,经抗癫痫、血液灌流等治疗后痊愈。头孢哌酮舒巴坦/他唑巴坦致肾衰竭病人抽搐主要为舒巴坦/他唑巴坦所致。结论 肾衰竭病人使用头孢哌酮舒巴坦/他唑巴坦的过程中,甚至疗程结束后一段时间内发生抽搐应考虑为舒巴坦/他唑巴坦不良作用所致的可能,给予血液灌流可有效治疗。 |
| 英文摘要: |
| Objective To investigate the clinical characteristics of the convulsion caused by cefoperazone-sulbactam/tazobactam in patients with renal failure and to analyze its causes.Methods Retrospective analyze the clinical manifestations,relationship between convulsive attack and drug use time and treatment of 12 hospitalized patients with renal failure who had convulsion after being used of efoperazone-sulbactam/tazobactam.Preliminary investigate the reason of convulsions caused by cefoperazone-sulbactam/tazobactam in patients with renal failure.Results Three patients had convulsions during the medication with cefoperazone-sulbactam/tazobactam for 3-10 days,while other 9 patients had convulsions during 2-8 days after the end of the course of treatment with the drug for 7-14 days.They all had loss of consciousness and recovered after treatment with anti-epilepsy,blood perfusion and so on.Convulsions caused by cefoperazone-sulbactam/tazobactam in patients with renal failure mainly induced by sulbactam or tazobactam.Conclusions Patients with renal failure have convulsions during the medication,even after the end of the course of treatment with cefoperazone-sulbactam/tazobactam.We should consider the drug side effects may be caused by sulbactam or tazobactam and blood perfusion flow should be taken as an effective therapy. |
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