| 史志辉,肖会敏,何悦,等.皮肤病血毒片制备中7种成分转移率研究[J].安徽医药,2017,21(7):1204-1208. |
| 皮肤病血毒片制备中7种成分转移率研究 |
| Study on transfer rates of 7 kinds of components in the preparation of pifubingxuedu tablet |
| 投稿时间：2016-12-28 |
| DOI： |
| 中文关键词: 皮肤病血毒片 高效液相色谱 绿原酸 芍药苷 连翘酯苷A 小檗碱 甘草酸 |
| 英文关键词: Pifubingxuedu tablet HPLC Chlorogenic acid Paeoniflorin Forsythiaside A Berberine Glycyrrhizin acid |
| 基金项目: |
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| 摘要点击次数: 2001 |
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| 中文摘要: |
| 目的 建立同时测定金银花、忍冬藤、红花、赤芍、白芍、川芎、当归、连翘、黄柏、甘草等药材与皮肤病血毒片中绿源酸、羟基红花色素A、芍药苷、连翘酯苷A、阿魏酸、小檗碱和甘草酸的含量测定方法,并探讨其在药材至皮肤病血毒片制剂间的转移率。方法 采用高效液相色谱(HPLC)及多波长方法；选取2批金银花、忍冬藤、红花、赤芍、白芍、川芎、当归、连翘、黄柏与甘草药材,每批对应5 批制剂。结果 (1)建立了HPLC 测定药材与制剂中7种成分的测定方法；(2)在药材至制剂间中的转移率绿源酸、羟基红花色素A、芍药苷、连翘酯苷A、阿魏酸、小檗碱和甘草酸分别为87.23%、86.35%、85.06%、86.95%、85.13%、91.70%、86.79%。结论 该含量测定方法简便、准确、重复性好,可作为药材与皮肤病血毒片中7种成分的定量方法；7种成分的转移率高,表明制剂制备工艺有利于该有效成分的转移,为制剂疗效提供了理论依据。 |
| 英文摘要: |
| Objective To establish a high performance liquid chromatography (HPLC) method for determining the contents of Chlorogenic acid,hydroxy Safflower Pigment A,paeoniflorin,forsythiaside A,ferulic acid,berberine and glycyrrhizin acid in Pifubingxuedu Tablet and the herbs of honeysuckle,honeysuckle,safflower,radix paeoniae rubra,Radix Paeoniae Alba,Rhizoma Chuanxiong,angelica,forsythia,phellodendron bark,licorice.Methods Using HPLC and multiwavelength method;selecting 2 batches of honeysuckle,honeysuckle,safflower,radix paeoniae rubra,Radix Paeoniae Alba,Rhizoma Chuanxiong,Radix Angelicae sinensis,Fructus Forsythiae,Cortex Phellodendri and Radix Glycyrrhizae,corresponding to each batch of 5 batch preparations.Results A HPLC method has been established for determining 7 components of medicinal materials and preparations;and the transfer rates of chlorogenic acid,hydroxy Safflower Pigment A,paeoniflorin,forsythiaside A,ferulic acid,berberine and glycyrrhizin were 87.23%,86.35%,85.06%,86.95%,85.13%,91.70% 86.79%,respectively,between the medicinal materials and preparation.Conclusions The HPLC method is suitable for the quality control of the preparation,and the transfer rate of the 7 components is high,which indicates that the preparation process is beneficial to the transfer of the active ingredient,and provides a theoretical basis for the preparation effect. |
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