| 张雁.左炔诺孕酮宫内缓释系统放置前应用促性腺激素释放激素激动剂对子宫腺肌症合并重度痛经及月经量的影响[J].安徽医药,2017,21(7):1211-1212. |
| 左炔诺孕酮宫内缓释系统放置前应用促性腺激素释放激素激动剂对子宫腺肌症合并重度痛经及月经量的影响 |
| Application effect of GnRHa before placing levonorgestrel releasing intrauterine system on severe dysmenorrhea and menstrual volume plus adenomyosis |
| 投稿时间：2016-07-20 |
| DOI： |
| 中文关键词: 左炔诺孕酮宫内缓释系统 重度痛经 促性腺激素释放激素激动剂 子宫腺肌病 |
| 英文关键词: The levonorgestrel releasing intrauterine system Severe dysmenorrhea GnRHa adenomyosis |
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| 摘要点击次数: 1956 |
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| 中文摘要: |
| 目的 观察使用左炔诺孕酮宫内缓释系统(LNG-IUS)治疗合并重度痛经子宫腺肌症病人前应用促性腺激素释放激素激动剂(GnRHa)对病人痛经缓解率、疼痛评分及月经量评分的疗效。方法 选取58例子宫腺肌病病人的完整临床资料作为研究对象。按病人经济情况及自愿情况将病人分为两组,分别为对照组和观察组,每组29例。对照组采用左炔诺孕酮宫内缓释系统治疗,观察组在左炔诺孕酮宫内缓释系统治疗前应用GnRHa治疗,比较两组病人的痛经缓解率、疼痛评分及月经量评分情况。结果 经治疗后,两组病人的痛经评分、月经失血图(PBAC)评分及痛经程度指标均明显下降,且治疗后观察组痛经程度指标下降幅度均大于对照组(P<0.05)。观察组的痛经缓解率为86.2%,高于对照组的痛经缓解率51.7%(P<0.05)。治疗后两组病人的子宫体积、子宫内膜厚度、CA125水平均明显下降,观察组病人的子宫体积、子宫内膜厚度、CA125水平均低于对照组,差异有统计学意义(P＜0.05)。 结论 在左炔诺孕酮宫内缓释系统前应用GnRHa治疗重度痛经子宫腺肌病病人效果良好,降低了病人的痛经缓解率,是一种有效治疗手段,安全性较高,值得临床推广。 |
| 英文摘要: |
| Objective To observe the application of gonadotropin releasing hormone agonist (GnRHa) before using levonorgestrel releasing intrauterine system (LNG-IUS) in patients with severe dysmenorrhea plus adenomyosis,and to explore its effect on dysmenorrhea relief rate,pain score and menstrual volume score.Methods The 58 cases with uterine gland disease were retrospectively analyzed with complete clinical data.According to the patients′ financial condition and the voluntariness,the patients were assigned into two groups,the control group and the observation group,29 cases in each group.Patients in control group were treated with levonorgestrel releasing intrauterine system,while patients in observation group adopted gonadal hormone releasing hormone agonist (GnRHa) treatment before using levonorgestrel releasing intrauterine system.Dysmenorrhea relief rate,pain score and menstrual volume scores were compared between two groups.Results After treatment,the two groups of patients had significantly decreased dysmenorrhea score,PBAC score and the degree of dysmenorrhea.Compared with the control group,the degree of dysmenorrhea index in the observation group after treatment decreased significantly (P<0.05).The remission rate of dysmenorrhea in the observation group was 86.2%,higher than 51.7% in the control group (P<0.05).After treatment,two groups of patients had significantly decreased uterine volume,endometrial thickness and CA125 levels.The uterine volume,endometrial thickness and CA125 levels of patients in observation group were significantly lower than the control group (P<0.05).Conclusions Application of promote gonadal hormone releasing hormone agonist (GnRHa) before using levonorgestrel releasing intrauterine system (LNG-IUS) in the treatment of severe dysmenorrhea patients with adenomyosis achieves good effect and reduces the dysmenorrhea rate of patients,which is an effective and safe method for treatment and is worthy of clinical promotion. |
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