| 杨燕.前列地尔对糖尿病下肢动脉硬化闭塞症病人下肢动脉内径和血流量的影响[J].安徽医药,2017,21(7):1299-1301. |
| 前列地尔对糖尿病下肢动脉硬化闭塞症病人下肢动脉内径和血流量的影响 |
| The clinical curative effect of alprostadil for treating patients with diabetes lower limb arteriosclerosis obliterans |
| 投稿时间：2017-01-16 |
| DOI： |
| 中文关键词: 糖尿病下肢动脉硬化闭塞症 前列地尔 内径 血流量 |
| 英文关键词: Diabetes lower limb arteriosclerosis obliterans Alprostadil Internal diameter Blood flow volume |
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| 中文摘要: |
| 目的 探讨前列地尔治疗糖尿病下肢动脉硬化闭塞症的临床疗效。方法 32例糖尿病下肢动脉硬化闭塞症病人,按随机数字表法分为两组,对照组16例常规治疗,控制饮食和降糖、调脂、抗炎,注射低分子肝素钙(每次5 000 U,每天2次,连用10 d),观察组16例在常规治疗上加用前列地尔静脉滴注,10 d为1个疗程,连续运用3个疗程后比较两组临床疗效。结果 观察组临床疗效优于对照组,有效率为87.5%,两组比较差异有统计学意义(P<0.05)。组内相比,治疗前后两组相关生化指标比较提示疗效较前增加,差异有统计学意义(P<0.05),但两组治疗前后双下肢动脉内径相比,差异无统计学意义(P>0.05)；双下肢动脉血流量、相关生化指标比较,治疗后观察组与对照组相比,差异有统计学意义(P<0.05)。结论 前列地尔能改善血流动力学,对糖尿病下肢动脉硬化闭塞症有确切的临床疗效。 |
| 英文摘要: |
| Objective To investigate the clinical curative effect of alprostadil on diabetes lower extremity arteriosclerosis obliterans.Methods Both groups use conventional treatment,including diet,glucose-lowering lipid adjusting treatment,anti-inflammatory drugs and low molecular heparin calcium (5 000 U every time,two time a day,ten days).Besides routine therapy,sixteen patients in the observational group were treated with intravenous drips alprostadil.There are ten days in one course.Then compare with the clinical effect between two groups after three courses of treatment.Results The effect of observational group is obviously higher than that of control group (P<0.05).The related metrics of the two groups cases after treatment than before treatment have increased (P<0.05).But the blood vessel diameter has no difference before and after the treatment (P>0.05).Group comparison analyses reveal that the difference is statistically significant (P<0.05).Conclusions Alprostadil can improve hemodynamics,which has exact curative effect on diabetes lower extremity arteriosclerosis obliterans. |
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