| 盛云艳,汪成琼,肖政,等.银杏达莫对原发性肾病综合征高凝状态影响的Meta分析[J].安徽医药,2017,21(7):1330-1334. |
| 银杏达莫对原发性肾病综合征高凝状态影响的Meta分析 |
| Effects of ginkgo injection on hypercoagulabale state in treatment for primary nephritic syndrome:A meta-analysis |
| 投稿时间：2016-11-12 |
| DOI： |
| 中文关键词: 银杏达莫注射液 原发性肾病综合征 高凝状态 Meta分析 |
| 英文关键词: Yinxingdamo injection Primary nephritic syndrome Hypercoagulabale state Meta-analysis |
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| 摘要点击次数: 1879 |
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| 中文摘要: |
| 目的 系统评价银杏达莫对原发性肾病综合征(PNS)高凝状态的影响。 方法 系统检索中国生物医学文献数据库(CBM)、中国知网(CNKI)、维普、万方、Cochrane、Embase、PubMed及SCI数据库,对纳入研究进行资料提取,并用Cochrane协作网RCT质量评价标准评价研究的质量。 结果 (1)纳入18个RCT,PNS共1 381例,纳入研究质量一般。(2)分析指标:高凝状态直接相关:血浆黏度、血小板聚集率、D-二聚体、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT),SMD值及95%CI分别为-2.08(-2.67,-1.49),-0.87(-1.55,-0.18), -1.40(-1.94,-0.85), -1.24(-1.58,-0.91),0.45(0.24,0.66),0.94(0.64,1.25);间接相关:血浆白蛋白、总胆固醇,SMD值及95%CI分别为0.80(0.27,1.32),-0.55(-0.90,-0.21)。分析指标组间均有统计学差异。(3)纳入1个研究报道轻微不良反应。 结论 与常规治疗组相比,银杏达莫可降低PNS的血浆黏度及调节高脂血症等,终缓解高凝状态,效果确切,临床应用前景广。 |
| 英文摘要: |
| Objective To systematically evaluate the influence of ginkgo injection on hypercoagulabale state in treatment for primary nephritic syndrome. Methods We retrieved all related studies in CBM,CNKI,VIP,Wanfang,Cochrane,Embase,PubMed and SCI.The quality of all included studies was evaluated by Cochrane scale and all data were analyzed by meta-analysis. Results 1) Eighteen RCTs involving 1381 patients with primary nephritic syndrome were included,with general methodological quality in most trials.2) Related indicators had a direct correlation with plasma viscosity,platelet aggregation rate,D-Dimer,FIB,APTT and PT,of which the merged SMD values and 95% CI of Meta-analysis were -2.08(-2.67,-1.49),-0.87(-1.55,-0.18),-1.40(-1.94,-0.85),-1.24 (-1.58,-0.91),0.45 (0.24,0.66),and 0.94 (0.64,1.25),respectively.They had an indirect correlation with plasma albumin and total cholesterol,of which the merged SMD values and 95% CI of Meta-analysis were 0.80(0.27,1.32),and -0.55(-0.90,-0.21).There were statistically significant differences between the groups.3)One study reported a light adverse reaction. Conclusions Our study shows that ginkgo injection can decrease the plasma viscosity,regulate hyperlipemia,so as to improve the hypercoagulable state in primary nephritic syndrome,which has wide application prospects. |
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