| 张峰.急性ST段抬高心肌梗死病人直接经皮冠状动脉介入同时给予替罗非班联合山莨菪碱治疗的疗效观察[J].安徽医药,2017,21(8):1501-1504. |
| 急性ST段抬高心肌梗死病人直接经皮冠状动脉介入同时给予替罗非班联合山莨菪碱治疗的疗效观察 |
| Effects of application combined with tirofiban and anisodamine on primary percutaneous coronary intervention in patients with acute ST segment elevation myocardial infarction |
| 投稿时间：2016-08-15 |
| DOI： |
| 中文关键词: 替罗非班 山莨菪碱 心肌梗死 冠状动脉 |
| 英文关键词: Tirofiban Anisodamine Myocardial infarction Coronary artery |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨冠脉内联合应用替罗非班和山莨菪碱治疗老年急性ST段抬高心肌梗死(ASTEMI)病人的可行性、安全性及临床效果。方法 将接受经皮冠状动脉介入(PPCI)治疗的72例老年ASTEMI病人采用随机数字表法均分为观察组和对照组两组,观察组行高剂量替罗非班联合山莨菪碱治疗,对照组行单纯高剂量替罗非班治疗,评价两组间出血风险差异、术后40 d内不良心血管事件(MACE)发生率以及术后1年内左心室射血分数(LVEF)；术后随访24~40个月,统计病人年再次住院次数,综合评价治疗效果。结果 术后两组病人均无严重出血及血小板减少症状；术后40 d观察组MACE发生率低于对照组(P＜0.05)；术后12个月两组LVEF比较差异有统计学意义(P＜0.01)；观察组随访期间年住院次数明显优于对照组(P＜0.01)。结论 老年ASTEMI病人PPCI时联合使用替罗非班与山莨菪碱可有效改善术后心功能,降低年再次住院次数。 |
| 英文摘要: |
| Objective To discusses the feasibility,safety and clinical effects of tirofibancombinedanisodamine on elderly patients with acute ST segment elevation myocardial infarction(ASTEMI). Methods 72 elderly ASTEMI patients treated with PPCI in our hospital were collected and divided into two groups by the random number table method.Study group was treated with high dose tirofiban and anisodamine.Control group wastreated with high dose tirofiban only.Effects between the two groups on bleeding risk,postoperative incidence of major adverse cardiovascular events(MACE) within 40 d and postoperative left ventricular ejection fraction(LVEF) within 1 year were evaluated.Rehospitalization time and therapeutic effect were observed in patients during 24-40 months follow-up. Results After PPCI,there were no serious hemorrhage and thrombocytopenia symptoms.Incidence of MACE in study group was lower than the control group(P＜0.05) on 40-day after PPCI.LVEF in study group was significantly higher than that of control group on 12-month after PPCI(P＜0.01).Rehospitalization time during follow-up in study group was significantly lower than that of control group(P＜0.01). Conclusion It can significantly improve postoperative cardiac function and reducerehospitalization time bytirofibancombined withanisodamine in elderly patients with ASTEMI. |
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