| 邓红星,林琳,邢代珍,等.何首乌中药制剂治疗高脂血症的临床疗效及其不良反应Meta分析[J].安徽医药,2017,21(9):1677-1682. |
| 何首乌中药制剂治疗高脂血症的临床疗效及其不良反应Meta分析 |
| A Meta-analysis for clinical efficacy and safety of Polygonum Multiflorum medicament for hyperlipidemiaDENG Hongxing1,LIN Lin2,XING Daizhen2,XIE Xuefeng1,LYU Xiongwen1 (1.School of Pharmacy,Anhui Medical University,Hefei,Anhui 230032,China; 2.The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China) Abstract:Objective |
| 投稿时间：2017-02-24 |
| DOI： |
| 中文关键词: 何首乌 高脂血症 不良反应 药物性肝损伤 Meta分析 |
| 英文关键词: Polygonum Multiflorum Hyperlipidemia Adverse reactions DILI Meta-analysis |
| 基金项目:国家自然科学基金项目(71503006);2016年高校领军人才引进与培育计划建设项目(gxbjZD2016032) |
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| 中文摘要: |
| 目的 评价何首乌中药制剂治疗高脂血症的有效性和安全性。 方法 通过计算机检索Medline、PubMed、万方数据知识服务平台、维普网、中国知网、中国生物医学文献数据库(CBM)等数据库和手工查阅的方式查找资料,汇总统计何首乌中药制剂和他汀类药物治疗高脂血症的临床随机对照试验数据文献,采用Stata 14.0软件对数据进行Meta分析。 结果 共纳入随机对照研究14篇文献,包括1 252例病例。Meta分析结果显示:何首乌中药制剂降低高脂血症患者血清总胆固醇(TC)的效果显著,总体治疗有效率和他汀类药物对照组比较差异无统计学意义(P=0.234,RR=1.087,95%CI区间为1.04～1.14)。 结论 何首乌中药制剂对高血脂症有一定的治疗效果,特别是降低胆固醇治疗的效果较确切,不良反应率方面与他汀类比较差异无统计学意义(1.1% vs 1.5%),临床需要在监测胃肠道和肝功能不良反应的前提下使用。 |
| 英文摘要: |
| Objective To evaluate the effectiveness and safety of Polygonum Multiflorum medicament in the treatment of hyperlipidemia. Methods Randomized controlled trials (RCT) data about the clinical efficacy of Polygonum Multiflorum medicament treating hyperlipidemia were collected by database retrieval and manual check,from Medline,PubMed,Wanfang data,VIP info,CNKI,Chinese biomedical literature (CBM) database,and so on.Stata 14.0 was applied for Meta-analysis. Results Fourteen studies involving 1 252 cases were included.Polygonum Multiflorum medicament showed remarkable effect on the serum total cholesterol (TC) which was similar to the effectiveness of statins;no statistical difference was found (P=0.234,RR=1.087,5%CI:1.04-1.14). Conclusions Polygonum Multiflorum medicament for the treatment of hyperlipidemia is generally safe and effective,especially obvious in decreasing serum level of TC.The adverse reaction rate is not statistically different from statins (1.1% vs 1.5%).It′s necessary to monitor clinically the gastrointestinal and hepatic adverse reactions of Polygonum Multiflorum medicament. |
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