| 胡海平,张磊,陈喜丽,等.金蝉止痒胶囊联合曲安奈德益康唑乳膏治疗湿热型肛周湿疹的疗效观察[J].安徽医药,2017,21(9):1712-1715. |
| 金蝉止痒胶囊联合曲安奈德益康唑乳膏治疗湿热型肛周湿疹的疗效观察 |
| Efficacy of jinchan zhiyang capsule combined with triamcinolone acetonide and econazole cream on the treatment of perianal eczema with damp-heat syndrome |
| 投稿时间：2016-09-27 |
| DOI： |
| 中文关键词: 金蝉止痒胶囊 曲安奈德益康唑乳膏 肛周湿疹 湿热型 |
| 英文关键词: Jinchan zhiyang capsule Triamcinolone acetonide econazole cream Perianal eczema Damp-heat type |
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| 中文摘要: |
| 目的 探讨金蝉止痒胶囊联合曲安奈德益康唑乳膏治疗湿热型肛周湿疹的疗效及对患者生活质量的改善。方法 将湿热型肛周湿疹患者120例按照随机数字表法分为对照组和观察组,每组60例。对照组采用曲安奈德益康唑乳膏治疗,早晚各1次。观察组在对照组基础上口服金蝉止痒胶囊,2～3粒/次,每天3次。两组患者连续治疗3周。比较两组临床症状评分、临床疗效及不良反应发生率,并用皮肤病生活质量指数量表(DLQI)评价两组生活质量。结果 治疗后,观察组患者的肛门瘙痒、肛周皮疹面积、皮疹形态、肛周渗液评分少于对照组(t=30.329、29.404、15.216、35.559,P＜0.001)。观察组总有效率为90%,高于对照组的73.33%(χ2=5.566,P=0.018)。观察组患者发生恶心等不良反应的发生率为6.7％,对照组为5.0％,两组比较差异无统计学意义(χ2=0.152,P=0.697)。治疗后1、2、3周,观察组患者的DLQI评分分别低于对照组,差异有统计学意义(t=15.688、33.044、34.771,P＜0.001)。结论 金蝉止痒胶囊联合曲安奈德益康唑乳膏治疗湿热型肛周湿疹可改善患者临床症状和生活质量,且安全性好。 |
| 英文摘要: |
| Objective To investigate the efficacy of jinchan zhiyang capsule combined with triamcinolone acetonide econazole cream in the treatment of damp-heat perianal eczema and to improve the quality of life of the patients.Methods One hundred and twenty patients with damp-heat perianal eczema were randomly assigned into control group and observation group,60 cases in each group.The control group was treated with triamcinolone acetonide econazole cream,once respectively each morning and evening.Observation group was treated with triamcinolone acetonide econazole cream and jinchan zhiyang capsule,2-3 tablets/time,3 times/d.Two groups of patients were continuously treated for 3 weeks.The clinical symptom score,clinical efficacy and adverse reaction rate were compared between the two groups.The quality of life (QOL) was assessed by the quality of life index (DLQI).Results After treatment,the anal pruritus,perianal rash area,rash form and perianal exudate score in the observation group were less than those in the control group (t=30.329,9.404,5.216,5.559,P<0.001).The total effective rate of the observation group was 90%,which was higher than that of the control group (χ2 =5.566,P=0.018).The incidence of nausea and other adverse events was 6.7% in the observation group and 5.0% in the control group.There was no significant difference between the two groups (χ2=0.152,P=0.697).The DLQI scores of the observation group were lower than those of the control group at 1 week,2 weeks and 3 weeks after treatment (t=15.688,3.044,4.771,P<0.001).Conclusions Jinchan zhiyang capsule combined with triamcinolone acetonide econazole cream in the treatment of damp-heat perianal eczema can improve the clinical symptoms and quality of life,which is safe for the patients. |
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