| 尹文杰,侯继秋,王虹.某院3 181例药品不良反应报告分析[J].安徽医药,2017,21(9):1739-1743. |
| 某院3 181例药品不良反应报告分析 |
| Adverse drug reactions in a hospital of China:a report of 3 181 cases |
| 投稿时间：2017-01-15 |
| DOI： |
| 中文关键词: 药品不良反应 用药分析 安全用药 |
| 英文关键词: Adverse drug reaction Drug analysis Safe medication |
| 基金项目: |
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| 中文摘要: |
| 目的 了解药品不良反应(ADR)发生的一般规律及特点,为临床合理用药提供参考。方法 采用回顾性分析方法,对3 181例ADR报告从ADR发生的年龄与性别分布、给药途径、药品种类、累及的系统/器官及临床表现、ADR报告类型及ADR转归等方面进行统计分析。结果 3 181例ADR报告中,男性1 501例(47.19%),女性1 680例(52.81%);ADR在各年龄段均有分布,＞50～60岁者ADR发生率最高,有829 例,占26.06%；引起ADR药品以抗感染药物居多,且主要为头孢菌素类,其次为心血管系统用药;引发ADR的给药途径以静脉滴注为主,占73.09%;ADR最常累及系统/器官为全身性损害,占23.07%；一般ADR占87.11%,大多好转或治愈,新的ADR占12.39%,严重ADR占0.69%,其中1 例留有后遗症,参麦注射液发生过敏性休克而死亡1例。结论 临床应高度重视ADR监测和报告工作,降低用药风险。 |
| 英文摘要: |
| Objective To explore the general rules and characteristics of adverse drug reactions (ADR),and to provide reference for clinical rational use of drugs.Methods A retrospective analysis was used to analyze the age and gender distribution,route of administration,type of drug,system/organ involved and clinical manifestations,ADR report type and ADR outcome of 3181 ADR reports.Results Of the 3 181 cases of ADR,1 501 cases were males (47.19%) and 1680 cases were females (52.81%).ADRs were distributed in all age groups,with the highest incidence in the age group above ＞50-60 years old (829 cases,26.06%).ADRs were mainly caused by anti-infective drugs,especially cephalosporins,followed by cardiovascular system medication.The main administration route causing ADR was intravenous infusion,accounting for 73.09%.The most often involved system/organ of ADR was systemic damage,accounting for 23.07%.General ADR accounted for 87.11%,mostly improved or cured,the new ADR accounted for 12.39%,and severe ADR accounted for 0.69%,of which 1 case had sequelae.There was 1 case of death caused by anaphylactic shock due to shenmai injection.Conclusions ADR monitoring and reporting should be attached great importance to reduce the risk of medication use. |
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