| 刘晓闯,张艳艳,高家荣,等.消炎去脂片不同工艺制备过程中指标成分含量变化研究[J].安徽医药,2017,21(11):1990-1993. |
| 消炎去脂片不同工艺制备过程中指标成分含量变化研究 |
| Study on effect of different process on the index component content of Xiaoyan quzhi tablets during processing |
| 投稿时间：2017-03-28 |
| DOI： |
| 中文关键词: 消炎去脂片 真空干燥 微波干燥 喷雾干燥制粒 湿法制粒 超高效液相色谱法 |
| 英文关键词: Xiaoyan quzhi tablets Vacuum drying Microwave drying Spray drying Wet granulation UPLC |
| 基金项目:安徽中医药大学临床科学研究基金项目(2012LC1-015B) |
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| 摘要点击次数: 2078 |
| 全文下载次数: 559 |
| 中文摘要: |
| 目的 考察消炎去脂片不同工艺制备过程中指标成分含量变化情况。方法 分别采用真空干燥、微波干燥对组方提取、浓缩制备的流浸膏进行干燥,制得干浸膏,再分别加辅料制备成颗粒,采用喷雾干燥制粒法将流浸膏直接喷雾干燥制粒,超高效液相色谱法(UPLC)检测消炎去脂片干浸膏、成品颗粒中黄芩苷和栀子苷的含量,考察真空干燥、微波干燥和喷雾干燥及制粒过程对指标成分含量变化的影响。结果 以组方中指标成分含量为指标,真空干燥含量均最低,喷雾干燥与微波干燥相近或互有高低。制粒、烘干过程对黄芩苷含量影响较大,而对栀子苷含量影响不大。结论 不同干燥方法及制粒、烘干工艺对中药制剂制备过程中指标成分含量均有影响,实际工艺研究中必须进行有效的筛选。 |
| 英文摘要: |
| Objective To compare effects of different process on the index component content of Xiaoyan quzhi tablets during processing. Methods Concentrated liquid extract of prescription extraction and preparation was dried by using vacuum drying and microwave drying for obtaining dry extract.Then dry extract and auxiliary materials were mixed to produce particles by spray drying granulating method.The contents of baicalin and gardenia of dry extracts and finished particle of Xiaoyan quzhi tablets were determined by ultra performance liquid chromatography (UPLC) to inspect the effect of vacuum drying,microwave drying,spray drying and granulation on the content changes of composition index. Results The index component con-tents of baicalin and gardenia in the formula as the index,the index component contents of baicalin and gardenia were the lowest by using vacuum drying,the index component contents of baicalin and gardenia were similar by using spray drying and microwave drying.Granulating and drying process have great influence on the content of baicalin,but have little effect on the content of geniposide. Conclusions The index component contents of Xiaoyan quzhi tablets can be affected by different drying methods and granulating,drying process,which showed that the selection of drying methods must be practical in the technology research. |
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