| 陈杰勇,石星媛,洪智峰,等.阿托伐他汀联合rhBNP治疗对急性心力衰竭患者血浆 TGF-β1与心功能的影响[J].安徽医药,2017,21(11):2085-2088. |
| 阿托伐他汀联合rhBNP治疗对急性心力衰竭患者血浆 TGF-β1与心功能的影响 |
| Effect of atorvastatin combined with rhBNP on plasma TGF-β1 and cardiac function in patients with acute heart failure |
| 投稿时间：2017-03-09 |
| DOI： |
| 中文关键词: 阿托伐他汀 外源性脑利钠肽 急性心力衰竭 血浆转化生长因子-β1 心功能 |
| 英文关键词: Atorvastatin rhBNP Acute heart failure Plasma TGF-beta 1 Cardiac function |
| 基金项目:佛山市医学类科技攻关项目(2014AB001431)阿托伐他汀联合rhBNP治疗对急性心力衰竭患者血浆 TGF-β1与心功能的影响陈杰勇1,石星媛1,洪智峰1,黎彩宜1,徐振峰2 (1.佛山市顺德区乐从医院,广东 佛山 528315；2.佛山市禅城区中心医院有限公司,广东 佛山 528315)阿托伐他汀联合rhBNP治疗对急性心力衰竭患者血浆 TGF-β1与心功能的影响陈杰勇1,石星媛1,洪智峰1,黎彩宜1,徐振峰2 Effect of atorvastatin combined with rhBNP on plasma TGF-β1 and cardiac function in patients with acute heart failureCHEN Jieyong1,SHI Xingyuan1,HONG Zhifeng1,LI Caiyi1,XU Zhenfeng2 |
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| 摘要点击次数: 2007 |
| 全文下载次数: 640 |
| 中文摘要: |
| 目的 研究急性心力衰竭(AHF)患者经阿托伐他汀与外源性脑利钠肽(rhBNP)治疗后血浆转化生长因子-β1(TGF-β1)与心功能的关系。方法 选择AHF患者116例,依据随机数字表法将患者分成观察组和对照组,各58例,两组均给予常规治疗,对照组加用阿托伐他汀,观察组在对照组的基础上另加用rhBNP治疗,对比两组血浆N末端脑钠肽原(NT-proBNP)及TGF-β1水平,心功能指标以及治疗前后的NYHA分级,分析指标间的相关性。结果 治疗后组内比较,两组的血浆NT-proBNP及TGF-β1水平均明显低于治疗前,差异有统计学意义(P＜0.05)。治疗后组间比较,观察组的血浆NT-proBNP(334.28±121.06) ng·L-1及TGF-β1水平(134.13±26.13)ng·L-1均明显低于对照组的(510.79±114.63) ng·L-1及(280.29±27.64) ng·L-1,差异有统计学意义(P＜0.05)。治疗后组内比较,两组的左室射血分数(LVEF)明显高于治疗前,左心室舒张末期容积(LVEDV)及左心室收缩末期容积(LVESV)水平明显低于治疗前,差异有统计学意义(P＜0.05)。治疗后组间比较,观察组的LVEF(40.74±5.18)%明显高于对照组的(38.20±3.25)%,LVEDV(105.24±11.38) mL及LVESV水平(51.29±9.36) mL明显低于对照组的(111.87±10.63) mL及(60.39±8.72) mL,差异有统计学意义(P＜0.05)。治疗后观察组的NYHA分级明显低于对照组,差异有统计学意义(P＜0.05)。根据Spearman法分析相关性发现,患者血浆NT-proBNP及TGF-β1均与NYHA分级呈正相关(r=0.721,0.764；均P＜0.05)。结论 阿托伐他汀联合rhBNP治疗AHF能够明显降低患者的血浆TGF-β1水平,并改善其心功能,效果明显,值得推荐。 |
| 英文摘要: |
| Objective To study the relationship between plasma TGF-β1 and cardiac function in patients with acute heart failure treated with atorvastatin and rhBNP. Methods One hundred and sixteen patients with AHF from March 2013 to September 2015 in Shunde District Lecong Hospital of Foshan City according to simple random number table method were assigned into observation group and control group,58 cases in each.Two groups were given conventional therapy.The control group was treated with atorvastatin while the observation group was given atorvastatin combined with rhBNP treatment.Plasma Nterminal brain natriuretic peptide(NT-proBNP),TGF-β1 level,cardiac function index,before and after the treatment of NYHA classification,as well as the correlation between indexes were compared and analyzed. Results After treatment,the plasma levels of NT-proBNP and TGF-β1 in the two groups were significantly lower than that before treatment.The differences were statistically significant(P＜0.05).After treatment,the plasma levels of NT-proBNP(334.28±121.06) ng·L-1 and TGF-β1(134.13±26.13) ng·L-1 in the observation group were significantly lower than those in the control group of(510.79±114.63) ng·L-1 and(280.29±27.64) ng·L-1,with the differences statistically significant(P＜0.05).After treatment,left ventricular shot ejection fraction(LVEF) was significantly higher than those before treatment in the treatment group,left ventricular diastolic end diastolic volume(LVEDV) and left ventricular end systolic volume(LVESV) levels were significantly lower than that before treatment,with statistically significant differences(P＜0.05).After treatment,the LVEF(40.74±5.18)% of the observation group was significantly higher than that of the control group of(38.20±3.25)%.LVEDV(105.24±11.38) mL and LVESV levels(51.29±9.36) mL were significantly lower than the control group of(111.87±10.63) mL and(60.39±8.72) mL,the differences of which were statistically significant(P＜0.05).After treatment,the NYHA grade of the observation group was significantly lower than that of the control group(P＜0.05).According to the correlation analysis of Spearman,the plasma NT-proBNP and TGF-β1 were positively correlated with NYHA grading(r=0.721,0.764；all P＜0.05). Conclusions Atorvastatin statins combined with rhBNP in the treatment of AHF can obviously reduce the patients′ plasma TGF-β1 levels,and improve cardiac function,which has great treatment effect and worth to give recommendation. |
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