| 陈福晖,刘达兴,容松.心肌缺血再灌注损伤发生机制的研究进展[J].安徽医药,2017,21(12):2145-2148. |
| 心肌缺血再灌注损伤发生机制的研究进展 |
| Research progress of myocardial ischemia-reperfusion injury mechanism |
| 投稿时间：2017-05-14 |
| DOI： |
| 中文关键词: 心肌缺血 再灌注损伤 发生机制 研究进展 |
| 英文关键词: Myocardial ischemia Reperfusion injury Pathogenetic mechanism Research progress |
| 基金项目:国家自然科学基金项目(81260056) |
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| 摘要点击次数: 3216 |
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| 中文摘要: |
| 随着社会的发展,物质水平的不断提高,不健康的饮食习惯、运动的缺乏、大量吸烟饮酒、精神压力过大等因素导致心血管疾病的发病率呈逐年增高趋势,严重威胁着人类的身体健康,而在心血管疾病的治疗过程中,心肌缺血再灌注损伤可加重原有的损伤,引起心肌细胞的结构及功能发生不可逆性改变,进而加重原有的心血管疾病,最终导致患者病情恶化甚至死亡,因此探讨缺血再灌注损伤的发生机制具有十分重要的意义。该文从氧自由基爆发、Ca2+超载、线粒体功能障碍、炎症、能量代谢障碍几个方面对心肌缺血再灌注损伤的发生机制作一综述,为临床上减轻缺血再灌注损伤提供一定的理论依据。 |
| 英文摘要: |
| With the development of the society and material level,the factors including unhealthy eating habits,lack of movement,excessive drinking and smoking and mental stress lead to the increased incidence of cardiovascular disease year by year,which seriously threaten human health.In the process of the treatment of cardiovascular disease,myocardial ischemia-reperfusion injury may increase the original damage,cause irreversible myocardial cell structure and function change,even worsen existing cardiovascular disease,eventually lead to deterioration and even death,so an exploratory examination of the mechanism of ischemia reperfusion injury is of great significance.In this paper,the mechanisms of myocardial ischemia-reperfusion injury were reviewed from several aspects such as the outbreak of oxygen free radicals,Ca2+ overload,mitochondrial dysfunction,inflammation,metabolic disorders energy,which provide certain theoretical basis for alleviating ischemia-reperfusion injury in clinical practice. |
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