| 陈江,任翼,何娜,等.B淋巴细胞亚群在儿童过敏原免疫治疗中的作用[J].安徽医药,2017,21(12):2189-2191. |
| B淋巴细胞亚群在儿童过敏原免疫治疗中的作用 |
| Role of Blymphocyte subsets in allergens immunotherapy of children |
| 投稿时间：2017-04-10 |
| DOI： |
| 中文关键词: 过敏原免疫治疗 B淋巴细胞 哮喘 过敏性鼻炎 |
| 英文关键词: Allergen immunotherapy B lymphocytes Asthma Allergic rhinitis |
| 基金项目: |
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| 中文摘要: |
| 目的 通过比较儿童过敏原免疫治疗前后B淋巴细胞亚群的变化,明确B细胞亚群在过敏原免疫治疗(AIT)治疗机制中的作用。方法 使用流式细胞计数法检测32例儿童过敏原免疫治疗前后1年B淋巴细胞亚群的数量,另选取32例年龄性别匹配的健康儿童作为对照组。结果 AIT治疗后活性B淋巴细胞的相对数和绝对数均明显低于治疗前水平(P=0.001),其余B淋巴细胞亚群治疗前后差异无统计学意义(P＞0.05)。结论 过敏原免疫治疗直接影响B淋巴细胞细胞分化,导致活性B细胞计数减少。活性B细胞计数或可作为AIT治疗效果及是否需要继续治疗的评估指标,具有重要的临床应用价值。 |
| 英文摘要: |
| Objective To compare the changes of Blymphocyte subsets in children before and after allergen immunotherapy (AIT),and to clarify the role of Bcell subsets in AIT treatment.Methods Flow cytometry was used to detect the number of Blymphocyte subsets in 32 children before and after allergen immunotherapy.Thirty-two healthy children with matched age and sex were selected as the control group.Results The relative and absolute numbers of activated Blymphocytes were significantly lower than those before treatment (P=0.001).There was no significant change in the other Blymphocyte subsets (P＞0.05).Conclusions Immunotherapy of allergens directly affects the differentiation of Blymphocytes,and results in a decrease in the activity of Bcells.Active Bcell count can be used as evaluation indicators in AIT treatment effect and whether there is the need for continued treatment,which has important clinical value. |
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