文章摘要
潘婷婷,徐春明,陈弹.单核细胞计数与高密度脂蛋白比值与冠脉病变的相关性分析[J].安徽医药,2017,21(12):2262-2265.
单核细胞计数与高密度脂蛋白比值与冠脉病变的相关性分析
Correlation of MHR with coronary artery lesions
投稿时间:2016-09-29  
DOI:
中文关键词: 炎症  冠脉狭窄  分析
英文关键词: Inflammation  Coronary stenosis  Analysis
基金项目:
作者单位
潘婷婷 苏州大学附属第一医院心血管内科,江苏 苏州 215006 
徐春明 苏州大学附属第一医院心血管内科,江苏 苏州 215006 
陈弹 苏州大学附属第一医院心血管内科,江苏 苏州 215006 
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中文摘要:
      目的 研究单核细胞计数与高密度脂蛋白比值(MHR)与冠脉病变程度的相关关系,并探讨MHR预测冠脉病变程度的价值。方法 将冠心病患者分为A组(Gensini<30分,55例)、B组(Gensini≥30分,55例),探讨MHR与冠脉病变的相关性,并预测高Gensini评分的价值。结果 B组MHR明显高于A组(P<0.05),相关性分析提示MHR与冠脉Gensini评分呈正相关(r=0.495,P<0.001),多因素Logistic分析显示糖尿病、MHR皆为高Gensini评分的独立危险因素,直接胆红素(DBil)则为保护性因素。ROC曲线显示MHR下的面积为0.767(95%CI:0.681~0.854),当MHR诊断临界值取9.45时,其诊断效率最高,敏感性为80%,特异性为60%。结论 患者冠脉病变程度越重,其MHR水平越高,且MHR可作为临床预测冠脉病变的重要参考指标。
英文摘要:
      Objective To study the correlation between monocyte/high density lipoprotein ratio (MHR) and the degree of coronary artery lesions,and to investigate the value of MHR in predicting the extent of coronary artery disease.Methods Patients with coronary heart disease (CHD) were assigned into two groups,group A (Gensini<30,n=55) and group B (Gensini≥30,n=55).The correlation of coronary lesions with MHR and its value of predicting high Gensini scores were analyzed.Results MHR of group Bwas noticeably higher than group A (P<0.05).Correlation analysis showed that MHR was positively correlated with the Gensini score (r=0.495,P<0.001).Multivariate Logistic analysis showed that diabetes and MHR were independent risk factors for high Gensini score,while direct bilirubin (DBil) was the protective one.The area under MHR of ROC curve was 0.767 (95%CI:0.681 to 0.854).And when the critical value of MHR was 9.45,the diagnostic efficiency reached the highest,with the sensitivity of 80%,and the specificity of 60%.Conclusions The more severe degree of coronary artery lesion is,the higher level of MHR will be.And MHR can be an important reference index to predict coronary artery lesion.
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