| 程序,倪伟建,张圣雨.应用糖皮质激素对风湿免疫病患者骨密度的影响研究[J].安徽医药,2017,21(12):2326-2328. |
| 应用糖皮质激素对风湿免疫病患者骨密度的影响研究 |
| Effect of glucocorticoids on the changes of bone mineral density in patients with rheumatic autoimmune disease |
| 投稿时间：2016-10-27 |
| DOI： |
| 中文关键词: 糖皮质激素 风湿免疫病 骨密度 钙剂 |
| 英文关键词: Glucocorticoids Rheumatological disease Bone mineral density Calcium |
| 基金项目: |
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| 中文摘要: |
| 目的 了解某三甲医院风湿免疫病患者用药情况,探讨糖皮质激素对风湿免疫病患者骨密度的影响,从而保障临床应用糖皮质激素治疗风湿免疫病的安全性、有效性、经济性与合理性。方法 抽取某院2015年1月——2016年1月150例风湿免疫病患者骨密度调查表,采用回顾性分析法分析患者前臂、股骨、脊柱三处骨密度与糖皮质激素使用量之间的关系,以及使用钙剂对患者骨密度的影响。结果 150例患者中男性14例,女性136例,平均病程6年；服用钙剂的人数占总例数的42%,服用糖皮质激素未服用钙剂骨密度下降人数占服用糖皮质激素总人数的32%,服用糖皮质激素并服用钙剂骨密度下降人数占服用糖皮质激素总人数的25%。类风湿关节炎和系统性红斑狼疮患者骨密度与糖皮质激素使用剂量差异有统计学意义(P＜0.05),强直性脊柱炎、干燥综合征与骨关节炎患者骨密度与糖皮质激素使用剂量不具相关性。结论 糖皮质激素对于类风湿关节炎和系统性红斑狼疮患者骨密度的丢失具有一定的影响,钙剂对糖皮质激素使用患者腰椎骨密度减少有预防性作用。 |
| 英文摘要: |
| Objective To investigate the medication situation and the effects of glucocorticoids (GCs) on bone mineral density of rheumatology patients of a Grade A,Class Three hospital,so as to guarantee the safe,economic,efficient and rational use of GCs.MethodsA retrospective cohort study was conducted using data of questionnaires on bone mineral density obtained from 150 rheumatic autoimmune patients between January 2015 and January 2016.We analyzed the relationship between the bone mineral density of forearm,femur,spine and the usage of GCs,and explored the effects of calcium on bone mineral density.Results Of 150 patients there were 14 males and 136 females,with an averaged 6-year course of disease.42% of the patients were taking calcium supplements.The percentage of patients who took corticosteroids but not calcium was 32% of the total,while the percentage of patients who took both corticosteroids and calcium was 25%.There was close relationship between the bone mineral density of the rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients and the dosage of GCs,however the bone mineral density of ankylosing spondylitis (AS),sjogren′s syndrome (SS) and osteoarthritis (OA) patients were not relative to the dosage of GCs.Conclusions Intake of GCs is related to the mineral density loss of RA and SLE patients.The application of calcium has a preventive effect on mineral density loss in the lumbar vertebra of the patients. |
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