| 刘祖霞,张斌,汪伟,等.丹红注射液治疗慢性心力衰竭患者的疗效及对血清TGF-β1和HMGB1水平的影响[J].安徽医药,2018,22(3):498-501. |
| 丹红注射液治疗慢性心力衰竭患者的疗效及对血清TGF-β1和HMGB1水平的影响 |
| Efficacy of benazepril combined with Danhong Injection in treating chronic cardiac failure and the influence on serum levels of TGF-β1 and HMGB1 |
| 投稿时间：2016-08-16 |
| DOI： |
| 中文关键词: 贝那普利 丹红注射液 慢性心力衰竭 转化生长因子β1 高迁移率族蛋白B1 |
| 英文关键词: benazepril Danhong Injections chronic heart failure transforming growth factor β1 high mobility group box B1 |
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| 中文摘要: |
| 目的 探讨贝那普利联合丹红注射液治疗慢性心力衰竭(CHF)患者的临床疗效及对血清转化生长因子β1(TGF-β1)和高迁移率族蛋白B1(HMGB1)水平的影响。 方法 将符合诊断条件的CHF患者85例,按随机数字法将患者分为对照组41例和观察组44例。两组给予常规治疗,对照组给予贝那普利每次5～10 mg,每天1次；观察组在对照组基础上采取丹红注射液每次40 mL,每天2次。两组患者连续治疗4周。比较两组6 min步行实验(6 MWT)、生活质量评分、心功能和临床疗效。检测两组血清TGF-β1和HMGB1水平。 结果 治疗后,观察组的6 MWT、左心射血分数(LVEF)和 E峰与A峰比值(E/A)显著高于对照组,生活质量评分、左室收缩末径(LVSEd)和左室舒张末径(LVDEd)明显低于对照组(P＜0.01)。观察组总有效率为97.73%,明显高于对照组80.49%(P＜0.05)。治疗后,观察组血清TGF-β1和HMGB1水平显著低于对照组,差异有统计学意义(P＜0.01)。 结论 贝那普利联合丹红注射液治疗CHF患者疗效显著,降低患者血清中TGF-β1和HMGB1水平可能与上述疗效相关。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy of benazepril combined with Danhong Injection in patients with chronic heart failure (CHF) and its effect on serum levels of transforming growth factor β1 (TGF-β1) and high mobility group box 1 (HMGB1). Methods Eighty-five CHF patients who met the diagnostic criteria were assigned into control group (n=41) and observation group (n=44) by random number method.The two groups were given routine treatment.The control group was given benazepril 5 to 10 mg once daily.The observation group took Danhong Injection 40 mL twice daily in addition to the same treatment in the control group.Two groups of patients were continuously treated for 4 weeks.The 6-minute walk test (6 MWT),quality of life score,cardiac function and clinical efficacy were compared between the two groups.Serum levels of TGF-β1 and HMGB1 were detected in both groups. Results After treatment,the 6 MWT,left ventricular ejection fraction (LVEF),and E/A ratio (E/A) in the observation group were significantly higher than those in the control group,and the quality of life scores,left ventricular end-systolic diameter (LVSEd) and left ventricular end-diastolic diameter (LVDEd) in the observation group were significantly lower than those in the control group (P <0.01).The total effective rate in observation group was 97.73%,which was significantly higher than that in control group (80.49%,P<0.05).After treatment,the levels of serum TGF-β1 and HMGB1 in the observation group were significantly lower than those in the control group (P<0.01). Conclusions Benazepril in combination with Danhong Injection in treating CHF has significant efficacy,which may be relevant to inhibiting serum levels of TGF-β1 and HMGB1. |
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