| 乔晓亮.血浆纤维蛋白原和鳞状细胞癌抗原在宫颈癌中的临床价值[J].安徽医药,2018,22(6):1123-1125. |
| 血浆纤维蛋白原和鳞状细胞癌抗原在宫颈癌中的临床价值 |
| Clinical significance of plasma fibrinogen levels and squamous cell carcinoma antigen in patients with cervical cancer |
| 投稿时间：2016-12-12 |
| DOI： |
| 中文关键词: 宫颈肿瘤 纤维蛋白原 肿瘤,鳞状细胞 抗原,肿瘤 |
| 英文关键词: Uterine cervical neoplasms Fibrinogen Neoplasms,squamous cell Antigens,neoplasm |
| 基金项目: |
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| 摘要点击次数: 2095 |
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| 中文摘要: |
| 目的 探讨血浆纤维蛋白原(FIB)和鳞状细胞癌抗原(SCCA)在宫颈癌中的变化及对于诊断的临床价值。 方法 选取经病理证实的宫颈癌患者62例(宫颈癌组),检测术前空腹血浆FIB和SCCA水平,同期选择宫颈良性病变患者50例(宫颈良性病变组)及健康体检者50例(健康对照组),观察各组血浆FIB和SCCA水平,并进行比较。同时,宫颈癌患者手术一周后再次检测血浆FIB和SCCA水平的变化。 结果 宫颈癌患者血浆FIB和SCCA水平分别为(4.40±1.29)g·L-1和(6.62±2.55) ng·mL-1,显著高于宫颈良性病变组及健康对照组,差异有统计学意义(F=53.772、132.072,P<0.05);血浆FIB和SCCA水平与宫颈癌恶性程度相关,分期Ⅲ～Ⅳ期患者血浆D二聚体水平明显高于l～Ⅱ期患者(P<0.01)；在手术1周后宫颈癌患者血浆FIB和SCCA水平较术前显著降低。 结论 宫颈癌患者手术前后其体内血浆FIB和SCCA水平变化显著,并且血浆FIB和SCCA水平变化趋势与宫颈癌的恶性程度呈正相关,因此血浆FIB和SCCA可以作为宫颈癌患者诊断、疾病监测及预后的指标。 |
| 英文摘要: |
| Objective To explore the changes and diagnostic significance of plasma fibrinogen (FIB) and squamous cell carcinoma antigen (SCCA) in patients with cervical cancer. Methods Sixty-two patients with cervical cancer (cervical cancer group),50 patients with thyroid benign lesions (benign cervical lesions group) and 50 healthy controls (healthy control group) were selected and included in our study.Plasma FIB and SCCA levels in different groups were tested and compared.At the same time,for patients with cervical carcinoma,the postoperative levels of plasma FIB and SCCA were monitored one week after surgery. Results The levels of plasma FIB and SCCA in patients with cervical cancer were (4.40±1.29) g·L-1,(6.62±2.55) ng·mL-1,respectively,which were significantly higher than those in thyroid benign lesions group and healthy control group (F=53.772,2.072,P<0.05).Plasma FIB and SCCA levels were correlated with malignant degrees of cervical carcinoma;patients in stage Ⅲ-Ⅳ had a higher level of plasma FIB and SCCA than those in stage I-Ⅱ (P<0.01).The postoperative levels of plasma FIB and SCCA in patients with cervical cancer were significantly decreased one week after surgery. Conclusions Plasma FIB and SCCA levels were obviously changed in cervical cancer patients before and after surgery,and were positively correlated with clinical stages.Thus,they can be used as an index of cervical cancer diagnosis,disease monitoring and prognosis. |
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