| 李芳,李伯恩.果糖二磷酸钠对脑出血患者的心肌酶谱的影响[J].安徽医药,2018,22(6):1145-1147. |
| 果糖二磷酸钠对脑出血患者的心肌酶谱的影响 |
| Effect of fructose sodium diphosphate on myocardium enzymogram in patients with cerebral hemorrhage |
| 投稿时间：2016-12-09 |
| DOI： |
| 中文关键词: 脑出血 果糖二磷酸盐类 心肌酶谱 |
| 英文关键词: Cerebral hemorrhage Fructosediphosphates Myocardium enzymogram |
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| 中文摘要: |
| 目的 探讨脑出血患者应用果糖二磷酸钠(FDP)对心肌酶谱的影响。 方法 选取脑出血患者64例,根据是否应用FDP分为对照组和治疗组,各32例,两组均给予常规治疗。其中治疗组在常规治疗的基础上给予果糖二磷酸钠(用法用量:5.0克/次,静脉滴注,2次/天,疗程7天),比较入院时第1天、第3天、第7天心肌酶谱乳酸脱氢酶(LDH )、磷酸肌酸激酶(CK)、门冬氨酸氨基转移酶 (AST)及磷酸肌酸激酶同工酶(CKMB)水平。 结果 心肌酶AST、LDH、CK及CKMB入院第3天治疗组的检测结果为:(46.41±27.53) IU·L-1、(285.94±42.84) IU·L-1、(352.81±148.69) IU·L-1、(37.47±12.05) IU·L-1；心肌酶AST、LDH、CK及CKMB入院第7天治疗组的检测结果为:(35.59±13.44) IU·L-1、(249.28±50.37) IU·L-1、(260.81±98.12) IU·L-1、(23.13±8.35) IU·L-1。入院第1天AST、LDH、CK及CKMB治疗组与对照组差异无统计学意义(P分别为0.504、0.935、0.672、0.588),第3、7天对照组AST、LDH、CK及CKMB均较治疗组升高,差异有统计学意义(第3天P分别为0.003、0.001、0.025、0.009；第7天P值分别为:0.001、0.013、0.013、0.001)。治疗组和对照组的AST、LDH、CK及CKMB第3天均较第1天时升高,差异有统计学意义(P<0.01),治疗组AST、LDH、CK及CKMB第7天与第1天相比较差异无统计学意义(P>0.05),对照组AST、LDH、CK、及CKMB第7天高于第1天,差异有统计学意义(P<0.01)。 结论 果糖二磷酸钠应用于脑出血患者可以降低急性期心肌酶谱,对心脏有保护作用。 |
| 英文摘要: |
| Objective To discuss the effect of fructose sodium diphosphate (FDP) on myocardium enzymogram in patients with cerebral hemorrhage. Methods Select 64 cases of cerebral hemorrhage patients,were randomly divided into control group and treatment group,In the two groups were given conventional treatment.The treatment group given fructose sodium diphosphate(Usage:5.0g, intravenous drip,bid,treatment course:7 day).Comparison on the first /third /seventh day of Myocardium enzymogram level:AST,LDH,CK,CKMB. Results The myocardium enzymogram AST、LDH、CK、and CKMB test results of treatment group in the thrid day:(46.41±27.53) IU·L-1、(285.94±42.84) IU·L-1、(352.81±148.69) IU·L-1、(37.47±12.05) IU·L-1;The myocardium enzymogram(AST、LDH、CK、and CKMB)test results of treatment group in the seventh day:(35.59±13.44) IU·L-1、(249.28±50.37) IU·L-1、(260.81±98.12) IU·L-1、(23.13±8.35) IU·L-1.There was no significant difference in the AST,LDH,CK,and CKMB on the first day of admission between control group and treatment group (P=0.504,0.935,0.672,0.588,respectively).The levels of AST,LDH,CK,and CKMB were significantly higher in the control group than those in the treatment group on the third and seventh day [(P=0.003,0.001,0.025,0.009) vs (P=0.001,0.013,0.013,0.001)].The levels of AST,LDH,CK,and CKMB of the control group and the treatment group on the third day were higher than those on the first day (P<0.01).There was no significant difference in the levels of AST,LDH,CK,and CKMBs in the treatment group between the first day and seventh day of admission (P>0.05).The levels of AST,LDH,CK,and CKMB in the control group on the seventh day of admission were higher than those on the first day;the difference had statistically significance (P<0.01). Conclusions The application of fructose sodium diphosphate in patients with cerebral hemorrhage can reduce the acute myocardium enzymogram and protect the heart. |
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