| 李查兵,王蕊.不同给药方法对帕洛诺司琼预防妇科手术术后恶心呕吐疗效的影响[J].安徽医药,2018,22(9):1796-1799. |
| 不同给药方法对帕洛诺司琼预防妇科手术术后恶心呕吐疗效的影响 |
| Effects of different administrations of palonosetron in prevention of nausea and vomiting after gynecological surgery |
| 投稿时间：2017-03-08 |
| DOI： |
| 中文关键词: 帕洛诺司琼 给药方式 妇科外科手术 术后恶心呕吐 |
| 英文关键词: Palonosetron Administion Gynecologic surgical procedures Palonosetron on nausea and vomiting |
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| 摘要点击次数: 1896 |
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| 中文摘要: |
| 目的 探讨帕洛诺司琼不同给药方式对于妇科手术患者术后恶心呕吐的防治效果。方法 选择择期妇科手术并行术后镇痛的患者60例,采用随机数字表法分为三组,其中A组仅在麻醉前静脉给予帕洛诺司琼75 μg；B组仅在镇痛泵中加入帕洛诺司琼75 μg；C组在麻醉前静脉给予帕洛诺司琼75 μg,并且在镇痛泵中加入帕洛诺司琼75 μg。记录术后12、24、36、48 h时静止和咳嗽时的疼痛VAS评分；同时记录0～12、12～24、24～36、36～48 h时间段内恶心、呕吐的发生次数以及术后48 h内发生头痛头晕、便秘、腹泻、嗜睡、口干、皮疹及锥体外系症状等不良反应的发生。结果 组内不同时间点和组间VAS评分差异无统计学意义。术后0～12、12～24和24～36 h A组和C组恶心、呕吐发生率均明显低于B组(P＜0.05)。三组患者术后均无头痛头晕、便秘、腹泻、嗜睡、口干、皮疹及锥体外系症状等不良反应的发生。结论 术前单次静脉注射帕洛诺司琼75 μg能够较好预防妇科手术术后48 h 内术后恶心呕吐的发生。 |
| 英文摘要: |
| Objective To investigate the effect of different administrations of palonosetron on nausea and vomiting(PONY) in postoperative patients with gynecological surgery.Methods 60 cases of patients undergoing elective gynecological surgery with postoperative analgesia,were randomly divided into 3 groups,intravenous infusion of patient controlled intravenous analgesia(PCIA ),30 min before operation,PCIA for analgesia of sufentanil 2 μg·kg-1.In group A,75 μg of palonosetron was given intravenously only before induction of anesthesia.In group B,75 μg of palonosetron was only added into PCIA.In group C,75 μg of palonosetron was given with intravenous infusion before anesthesia induction,and 75 μg of palonosetron was added into the PCIA.The VAS scores of resting and coughing pain were recorded at 12 h,24 h,36 h,and 48 h postoperatively.The number of PONV occurred at 0-12 h,12-24 h,24-36 h and 36-48 h.And the occurrence of headaches,dizziness,constipation,diarrhea,drowsiness,dry mouth,rash and extrapyramidal symptoms within 48 hours.Results There were significant differences in the incidence of PONV between group A,C and Bgroup in postoperative 36 h (P＜0.05).All patients in the three groups had no adverse reactions of headache and dizziness,constipation,diarrhea,drowsiness,dry mouth,rash and extrapyramidal symptoms.Conclusion Preoperative single intravenous injection of palonosetron 75 μg can be a good prevention of the occurrence of PONV of 48 hours after gynecological surgery. |
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