| 刘渝,郑秀惠,王婉,等.宫颈癌及宫颈上皮内瘤变患者术后复发与高危型人乳头瘤病毒载量和持续阳性的相关性研究[J].安徽医药,2018,22(11):2102-2105. |
| 宫颈癌及宫颈上皮内瘤变患者术后复发与高危型人乳头瘤病毒载量和持续阳性的相关性研究 |
| Research on the relationship between postoperative relapse of cervical cancer and cervical intraepithelial neoplasia and the high risk of HR-HPV viral load and continuous positive |
| 投稿时间：2017-12-17 |
| DOI： |
| 中文关键词: 宫颈癌 宫颈上皮内瘤变 高危型人乳头瘤病毒 复发 |
| 英文关键词: Cervical cancer Cervical intraepithelial neoplasia High-risk human papilloma virus Relapse |
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| 摘要点击次数: 1911 |
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| 中文摘要: |
| 目的 探讨宫颈癌及宫颈上皮内瘤变(CIN)患者术后复发与术前高危型人乳头瘤病毒(HR-HPV)病毒载量、术后HR-HPV持续阳性的关系。方法 收集2013年1月至2015年6月于陆军军医大学第三附属医院行HR-HPV检查的191例宫颈癌及521例CIN患者资料,给予治疗并定期随访,分析不同病毒载量术后转阴的差异,探讨HR-HPV持续阳性、术前病毒载量与宫颈病变复发的相关性。结果 宫颈癌患者术后2年HR-HPV转阴率为97.3%,CIN患者术后2年HR-HPV转阴率为91.1%；宫颈癌及CIN患者病毒载量与术后HR-HPV转阴率均差异无统计学意义(r=-0.107,P＞0.05;r=-0.399,P＞0.05)；logistic回归分析显示宫颈癌及CIN术后复发与术前病毒载量比较差异无统计学意义(OR=1,P＞0.05;OR=1,P＞0.05)；宫颈癌术后复发与HR-HPV持续阳性相关联(OR=6.631,P=0.000)；CIN术后复发与HR-HPV持续阳性密切关联(OR=18.926,P=0.000)。结论 宫颈病变复发与术前病毒载量无明显关联,而与术后HR-HPV持续阳性密切关联,如术后HR-HPV持续阳性需警惕宫颈病变的复发。 |
| 英文摘要: |
| Objective To explore the relationship between postoperative relapse of cervical cancer and cervical intraepithelial neoplasia (CIN) and the high risk of high-risk human papilloma virus (HR-HPV) viral load and continuous positive.Methods One hundred and ninety-one cases of cervical cancer patients and 521 cases of CIN patients in Institute of Surgery Research,Third Affiliated Hospital,Army Medical University (Third Military Medical University) from January 2013 to June 2015 were selected.The patients were treated and regularly followed up to analyze the difference in viral load postoperative HR-HPV clearance rate,and to discuss the relationship between HR-HPV preoperative viral load and continuous positive rate and the relapse of cervical lesions.Results The rate of HR-HPV clearance rate was 97.3% for cervical cancer patients at 2 years after surgery and 91.1% for CIN patients at 2 years after surgery.Cervical cancer and CIN patients postoperative HR-HPV viral load and clearance rate had no significant differences (r=-0.107, P＞0.05;r=-0.399,P＞0.05);Logistic regression analysis concluded that cervical cancer and CIN patients postoperative relapse and preoperative viral load had no significant differences (OR=1,P＞0.05;OR=1,P＞0.05);the relapse of postoperative cervical cancer patients was relevant to HR-HPV continuous positive rate (OR=6.631,P=0.000);the postoperative relapse of CIN patients was relevant to HR-HPV continuous positive rate (OR=18.926,P=0.000).Conclusion The relapse of cervical lesions was not relevant to preoperative viral load,but it was closely related to HR-HPV continuous positive.Therefore,postoperative HR-HPV continuous positive should be alert to the relapse of cervical lesions. |
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