| 余项华,马广泉,刘琥,等.富血小板血浆治疗骨缺损的临床研究[J].安徽医药,2018,22(11):2184-2187. |
| 富血小板血浆治疗骨缺损的临床研究 |
| A study of bone defect by treatment with PRP |
| 投稿时间：2016-11-30 |
| DOI： |
| 中文关键词: 富血小板血浆 骨缺损 同种异体骨移植 |
| 英文关键词: Platelet-rich plasma Bone defect Allogeneic bone graft |
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| 摘要点击次数: 1857 |
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| 中文摘要: |
| 目的分析富血小板血浆(PRP)治疗骨缺损的临床效果。方法 选择2012年1月至2015年12月期间青海省交通医院骨科收治的骨缺损患者120例作为研究对象,将120例骨缺损患者按照随机数字表法分为观察组和对照组,每组60例,观察组使用同种异体骨移植和同体积的PRP治疗,对照组仅使用同种异体骨移植。分析两组患者骨融合情况,并通过简化McGill疼痛问卷量表对两组患者情感、感觉疼痛评分进行比较。结果 1个月、3个月、6个月、9个月后复查X片、CT,两组骨融合情况差异有统计学意义(χ2=4.227,P=0.040；χ2=23.404,P=0.000；χ2=16.895,P=0.001；χ2=11.407,P=0.002),3个月、6个月后观察组和对照组感觉疼痛评分差异有统计学意义[(12.45±3.57)分vs.(17.61±3.69)分,t=7.785,P=0.001；(9.27±2.61)分 vs.(10.21±1.76)分,t=2.313,P=0.023],3个月后观察组和对照组情感疼痛评分差异有统计学意义[(6.25±0.52)分vs.(7.43±0.63)分,t=11.190,P=0.001]。结论 PRP治疗骨缺损能促进患者骨融合,缓解患者感觉疼痛。 |
| 英文摘要: |
| Objective To analyze the clinical effect of platelet-rich plasma (PRP) in the treatment of bone defect.Methods One hundred and twenty patients with bone defect treated in the Department of Orthopedics,Traffic Hospital of Qinghai from January 2012 to December 2015 were chosen as study objects and randomly assigned into observation group and control group,60 cases in each group.The observation group was treated with allogeneic bone graft and the same volume of PRP treatment while the control group treated with allogeneic bone graft only.Bone fusion was analyzed in the two groups.The Simplified McGill Pain Questionnaire (SF-MPQ) was used to compare the scores of emotional and sensory pain between the two groups.Results X-ray and CT were reviewed after 1 month,3 months,6 mouths and 9 mouths.There were significant differences between the observation group and control group in bone fusion (χ2=4.227,P=0.040;χ2=23.404,P=0.000;χ2=16.895,P=0.001;χ2=11.407,P=0.002).The scores of sensory pain of the observation group and control group were significant different after 3 months and 6 months [(12.45±3.57) vs.(17.61±3.69),t=7.785,P=0.001;(9.27±2.61) vs.(10.21±1.76),t=2.313,P=0.023].There was significant difference between the observation group and control group in emotional pain scores after 3 months [(6.25±0.52) vs.(7.43±0.63),t=11.190,P=0.001].Conclusion PRP treatment of bone defects can promote bone fusion in patients and reduce the pain in patients. |
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